PMID: 1551307Jan 1, 1992Paper

The influence of hypoglycaemic agents on the growth and metabolism of human endothelial cells

Diabetic Medicine : a Journal of the British Diabetic Association
R G Petty, J D Pearson


Using human umbilical vein endothelial cells, and human microvascular endothelial cells from omental and subcutaneous fat obtained at laparotomy, we studied the effects of sulphonylureas and the biguanide metformin on endothelial cell proliferation, prostacyclin production, ecto-5'-nucleotidase activity, and von Willebrand factor release. Each drug produced a concentration-dependent proliferation of umbilical vein but not of microvascular endothelial cells. The stimulation of umbilical vein endothelial cell proliferation by sulphonylureas, but not by metformin, was serum- and insulin-dependent. Sulphonylureas and metformin had no effect on the proliferation of human dermal fibroblasts, smooth muscle cells derived from the umbilical artery, or 3T3 cells, until concentrations greater than 100 fold those found in vivo were reached, when there was inhibition of proliferation. These agents had no effect on prostacyclin or von Willebrand factor production, or on ecto-5'-nucleotidase activity, until high concentrations were used, at levels which also inhibited proliferation. The results suggest that the sulphonylureas and metformin, may, at concentrations found in vivo, induce changes in the turnover of endothelial cells from large ve...Continue Reading


Jan 1, 1979·Metabolism: Clinical and Experimental·E G LufkinE J Bowie
Jan 1, 1979·Thrombosis Research·E G Levin, D J Loskutoff
Apr 1, 1975·Diabetologia·R N BanerjeeJ Bardhan
Feb 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K TakahashiJ Hata
Feb 15, 1989·Thrombosis Research·B E PottingerJ D Pearson
Jan 1, 1985·Annual Review of Physiology·J D Pearson, J L Gordon
Aug 1, 1987·Diabetologia·M PortaG M Molinatti
Sep 1, 1973·The Journal of Clinical Investigation·D P Singal, S Goldstein
Nov 1, 1983·The Journal of Pathology·A M Schor, S L Schor
Jun 1, 1983·The Journal of Clinical Investigation·P A KernR H Eckel
Jul 1, 1984·Drugs·A C Asmal, A Marble
Dec 6, 1984·The New England Journal of Medicine
Dec 1, 1983·The Tohoku Journal of Experimental Medicine·K KawaguchiH Uzawa
Sep 6, 1984·The New England Journal of Medicine·J F Mustand, M A Packham
Sep 1, 1980·The Journal of Clinical Investigation·M J Prince, J M Olefsky
Jan 1, 1982·Current Medical Research and Opinion·F VioliE Vezza
Aug 1, 1981·The Journal of Cell Biology·J J CastellotM J Karnovsky

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