The influence of hypoxic physical activity on cfDNA as a new marker of vascular inflammation

Archives of Medical Science : AMS
Andrzej PokrywkaMaciej Banach

Abstract

The phenomenon of circulating cell-free DNA (cfDNA) is important for many biomedical disciplines including the field of exercise biochemistry and physiology. It is likely that cfDNA is released into the plasma by apoptosis of endothelial cells and circulating endothelial progenitor cells (EPCs), and/or by NETosis of immune cells induced by strenuous exercise. Increases of cfDNA are described to be a potential hallmark for the overtraining syndrome, and might be related to aseptic vascular inflammation in athletes. Yet, the relevance of systemic inflammation and cfDNA with endothelial dysfunction in athletes still remains unclear. In this review article, we provide a current overview of exercise-induced cfDNA release to the circulation with special emphasis on its relationship with apoptosis and NETosis and the effect of hypoxic physical activity on vascular inflammation in athletes.

Citations

Jan 28, 2017·Current Opinion in Genetics & Development·Timothy M ButlerJoe Gray
Mar 17, 2020·Journal of Sports Sciences·Larry A Tucker
May 24, 2019·Intensive Care Medicine Experimental·Nicholas L Jackson ChornenkiPatricia C Liaw
Jan 27, 2021·Toxicon : Official Journal of the International Society on Toxinology·Êndila de Souza BarbosaJacqueline de Almeida Gonçalves Sachett

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis