The Influence of IL-1B Gene Polymorphisms on H. pylori Infection and Triple Treatment Response Among Jordanian Population

The Application of Clinical Genetics
Muhamad Ali K ShakhatrehMahmoud Mahafdah

Abstract

Helicobacter pylori (H. pylori) is considered the main cause of gastritis, peptic ulcer and gastric carcinoma in the human populations. H. pylori infection influences the secretion level of several proinflammatory cytokines including IL-1β, which encoded by the IL-1B gene. The current study aimed to investigate whether IL-1B gene polymorphisms are associated with H. pylori infection among the Jordanian population and responses to triple therapy. The gastroscopic examination was performed on 412 subjects for H. pylori infection diagnosis, 257 subjects were found to be infected by H. Pylori (positive cases), whereas 155 subjects were uninfected (negative controls). The IL-1B gene T-31C and C3954T polymorphisms were genotyped by PCR-RFLP. It was found that the T-31C polymorphism has a significant association with H. pylori infection (P<0.05), and the TT genotype frequency was significantly higher in infected subjects (50.2%) compared to controls (38.7%). On the other hand, no significant association was detected between C3954T SNPs and H. pylori infection among the Jordanian population. In addition, none of the examined polymorphisms were found to influence the responses to triple therapy. The IL-1B gene T-31C SNP might be associa...Continue Reading

References

Sep 11, 1987·The American Journal of Physiology·Y S GuoJ C Thompson
Apr 1, 1997·Alimentary Pharmacology & Therapeutics·J C Atherton
Jul 31, 2001·Fertility and Sterility·L A HeflerJ C Huber
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Takahisa FurutaKyoichi Ohashi
Nov 20, 2004·International Journal of Cancer. Journal International Du Cancer·Young-Woon ChangRin Chang
Feb 17, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Mitsushige Sugimoto, Yoshio Yamaoka
Jul 17, 2009·Expert Opinion on Biological Therapy·Kathrin MaedlerJoachim Størling
Feb 9, 2010·Journal of Gastroenterology and Hepatology·Mitsushige SugimotoYoshio Yamaoka
Jun 21, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J C SantosM L Ribeiro
Jun 29, 2012·BMC Physiology·Kristin J Speaker, Monika Fleshner
Oct 2, 2012·Journal of Gastroenterology and Hepatology·Jin Joo KimHyun Chae Jung
Oct 24, 2012·Journal of Korean Medical Science·Hae Yeon KangIn Sung Song
Jun 21, 2013·International Journal of Clinical Pharmacology and Therapeutics·Karem H AlzoubiNizar Mhaidat
Jan 1, 2014·World Journal of Gastroenterology : WJG·Yang ZhaoYu-Min Li
May 8, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Agostinho Caleman NetoSpencer Lm Payão
Sep 5, 2014·Experimental and Therapeutic Medicine·Omar F KhabourFarah Alhashimi
Dec 5, 2014·World Journal of Gastroenterology : WJG·Chao-Hung KuoFu-Chen Kuo
Feb 24, 2015·Annals of Translational Medicine·Ju Yup Lee, Nayoung Kim
Apr 25, 2015·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Gülhan AkçilAyşe Dursun
Sep 12, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu-Mei WangKai-Feng Pan
Nov 1, 2015·Journal of Infection in Developing Countries·Ivy Bastos RamisPedro Eduardo Almeida Da Silva
Jan 23, 2016·World Journal of Gastrointestinal Oncology·Natale FiguraAntonio Ponzetto
May 25, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Bo ChenGuo-Qiang Su
Sep 12, 2017·Helicobacter·Jean-Dominique de KorwinAntonio Gasbarrini
Sep 12, 2018·Helicobacter·Marino VeneritoPeter Malfertheiner
Sep 27, 2018·World Journal of Clinical Oncology·Breno Bittencourt de BritoFabrício Freire de Melo
Oct 14, 2018·Microbial Pathogenesis·Sandeep Kumar, Monisha Dhiman

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
genotyping
PCR

Software Mentioned

SNPstat
Power

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.