The influence of immunizing dose size and schedule on immunity to subsequent challenge with antigenically distinct strains of Eimeria maxima

Avian Pathology : Journal of the W.V.P.A
D P BlakeAdrian L Smith

Abstract

Eimeria maxima, the most immunogenic of the Eimeriidae that infect the chicken, is characterized by the presence of antigenic diversity within field isolates. In priming/challenge experiments immunity to homologous infection is essentially complete while immunity against challenge by a heterologous strain is often only partial. The phenotype "escape from immune protection" is known to be influenced by both host and parasite genotypes but the impact of varied immunization dose and schedule remains poorly documented. In this manuscript we report that an immunizing dose between <or=5 and <or=20 sporulated E. maxima oocysts is consistently capable of stimulating complete (>99.99%) protective immunity against challenge by 100 oocysts of a homologous strain. In contrast, complete immunity against a heterologous strain was never observed, although increasing the immunizing dose size did frequently reduce oocyst production arising from subsequent heterologous challenge. Differences in cross-protective immunizing capacity between two strains of E. maxima were evident as the H strain consistently stimulated a more potent protective immune response than the W strain. Similarly, increasing the number of immunizing doses of the E. maxima W ...Continue Reading

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Citations

Apr 3, 2012·Molecular and Biochemical Parasitology·Damer P BlakeKiew-Lian Wan
Aug 31, 2010·Veterinary Parasitology·F C VelkersJ A P Heesterbeek
May 20, 2015·Veterinary Parasitology·Damer P Blake
Feb 12, 2010·Experimental Parasitology·F C VelkersM C M de Jong
Dec 12, 2018·Frontiers in Genetics·Kay BoultonAndroniki Psifidi
Mar 17, 2020·Frontiers in Veterinary Science·Francesca SoutterDamer P Blake

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