The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients

Mediators of Inflammation
Joana Maira Valentini ZacariasAna Maria Sell

Abstract

A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) and IL17F T7488C (rs763780) polymorphisms and periodontitis. Genotypes were determined by PCR-RFLP method. Statistical analyses were conducted using the OpenEpi and SNPStas software to calculate Chi-square with Yates correction or Fisher's exact tests, odds ratios (OR), and 95% confidence intervals (CIs). SNPStas software was used to calculate Hardy-Weinberg equilibrium. IL17A AA genotype was more frequent in patients with chronic periodontitis (CP) in the codominant and recessive models (P = 0.09; OR = 2.53 and P = 0.03; OR = 2.46, resp.), the females with CP (P = 0.01, OR = 4.34), Caucasoid patients with CP (P = 0.01, OR = 3.45), and nonsmoking Caucasian patients with CP (P = 0.04, OR = 3.51). The IL17A A allele was also more frequent in Caucasians with CP (P = 0.04, OR = 1.59). IL17F T7488C polymorphism was not associated with chronic periodontitis. In these patients from Southern Brazil, the IL17A rs2275913 polymorphisms, IL17A AA genotype, and the A allele were associated with a susceptibility to chronic periodontitis.

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Citations

Oct 14, 2017·Molecular Biology Reports·Felipe Rodolfo Pereira da SilvaDaniel Fernando Pereira Vasconcelos
May 5, 2017·Journal of Immunology Research·Pâmela Guimarães ReisJeane Eliete Laguila Visentainer
Oct 12, 2018·Annals of Human Genetics·Julimary Suematsu AquinoJeane Eliete Laguila Visentainer
Feb 12, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ebrahim Eskandari-NasabArezoo Tahmasebi
Feb 4, 2021·International Journal of Environmental Research and Public Health·Małgorzata Mazurek-MocholAndrzej Pawlik
Jul 3, 2021·Journal of Personalized Medicine·Janisleya Silva Ferreira NevesAna Maria Sell
Sep 24, 2021·Molecular Biology Reports·Isabela Bronchtein GomesCinara Cássia Brandão

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Methods Mentioned

BETA
genotyping
electrophoresis

Software Mentioned

SNPStas
OpenEpi

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