PMID: 8974001Dec 1, 1996Paper

The influence of interleukin-6 on the growth of human esophageal cancer cell lines

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
M OkaT Suzuki

Abstract

We reported that human esophageal cancer cell lines (ECC) (YES-1, -2, -3, -4, -5, and -6) produced interleukin-6 (IL-6). We, therefore, investigated the growth effects ([3H]thymidine uptake assay and direct cell count) of IL-6 on these ECC. IL-6 receptor (R) and GP-130 mRNA were detected in all the ECC, using reverse transcriptase-polymerase chain reaction (RT-PCR) assay, and IL-6R was detected in one (YES-3) by immunohistochemical staining. IL-6, anti-IL-6 monoclonal antibody (mAb), or anti-IL-6R mAb caused no reproducible enhancement or suppression of [3H]thymidine uptake by all six ECC. Direct cell count also revealed that the growth enhancement or suppression by IL-6, anti-IL-6 mAb, or anti-IL-6R mAb was relatively small. Particularly, there was no significant sensitivity of YES-3 cells, which definitely produce IL-6 and express IL-6R for IL-6, anti-IL-6 mAb, or anti-IL6R mAb. These results suggest that some esophageal cancers may produce IL-6 and express IL-6R. However, no major interactions between IL-6 and the growth of human esophageal cancer cell lines were detected in this study.

References

Aug 1, 1992·European Journal of Immunology·H SuzukiT Kishimoto
Feb 6, 1985·Nature·M B Sporn, A B Roberts
Nov 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M OkaT Suzuki

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Citations

May 12, 2006·World Journal of Gastroenterology : WJG·Maurizio SoresiGiuseppe Montalto
Sep 8, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M Łukaszewicz-ZającM Szmitkowski
Sep 2, 2011·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Hidefumi KitaTomoyuki Goya
Dec 1, 2010·European Journal of Clinical Investigation·Chih-Ping HsuYuan-Chiang Chung
Sep 4, 2012·International Journal of Molecular Sciences·Hong-Yan JiaHao-Liang Zhao
Mar 1, 2016·Oncogene·E W LinA K Rustgi
Jul 28, 2005·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P Guillem, J P Triboulet
May 23, 2009·International Journal of Cancer. Journal International Du Cancer·Hiromichi YamaiAkira Tangoku
Nov 28, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Shegan GaoXiaoshan Feng
Jun 15, 2004·Cancer Letters·Hiroaki ToshimitsuKohsuke Sasaki
Jul 27, 2007·Biochemical Pharmacology·Jongsung LeeDeokhoon Park
Nov 5, 2003·Clinical Lung Cancer·Santiago Ballaz, James L Mulshine
May 23, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Magdalena GroblewskaMaciej Szmitkowski

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