The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology.

American Journal of Physiology. Renal Physiology
Lisa L AblerChad M Vezina

Abstract

We used male BTBR mice carrying the Lepob mutation, which are subject to severe and progressive obesity and diabetes beginning at 6 wk of age, to examine the influence of one specific manifestation of sleep apnea, intermittent hypoxia (IH), on male urinary voiding physiology and genitourinary anatomy. A custom device was used to deliver continuous normoxia (control) or IH to wild-type and Lepob/ob (mutant) mice for 2 wk. IH was delivered during the 12-h inactive (light) period in the form of 90 s of 6% O2 followed by 90 s of room air. Continuous room air was delivered during the 12-h active (dark) period. We then evaluated genitourinary anatomy and physiology. As expected for the type 2 diabetes phenotype, mutant mice consumed more food and water, weighed more, and voided more frequently and in larger urine volumes. They also had larger bladder volumes but smaller prostates, seminal vesicles, and urethras than wild-type mice. IH decreased food consumption and increased bladder relative weight independent of genotype and increased urine glucose concentration in mutant mice. When evaluated based on genotype (normoxia + IH), the incidence of pathogenic bacteriuria was greater in mutant mice than in wild-type mice, and among mice e...Continue Reading

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Citations

Aug 3, 2021·Physiological Reports·Hannah M RuettenChad M Vezina

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Methods Mentioned

BETA
lavage
urine spot
genotyping

Software Mentioned

Void Whizzard
FIJI
VisonWorks LS
UVP
AxoScope Application
GraphPad Prism
pCLAMP

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