The influence of intraoperative frozen section analysis in patients with total or extended maxillectomy

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
James MurphyJoshua E Lubek

Abstract

Intraoperative frozen sections and final pathology may influence treatment with regards to intraoperative and postoperative treatments, respectively. A retrospective study comparing intraoperative frozen section analysis with final pathologic analysis in patients who had total or extended maxillectomies for malignant disease between 2008 and 2013. Twenty-five patients met the inclusion criteria. The mean age was 67.8 years. The majority of patients (76%) had stage IV disease (American Joint Committee on Cancer [AJCC] staging). Intraoperative frozen sections were positive in 24% (n = 6) compared with 60% (n = 15) on final pathologic analysis. Frozen section analysis had a sensitivity of 40%. Positive margins were resected where possible, unless limited by proximity to vital structures. Patients were statistically more likely to follow a recommendation for adjuvant therapy (P < .05) compared with adjuvant chemotherapy (P > .05). Intraoperative frozen section analyses are unreliable in predicting positive margins in patients with late-stage maxillary malignancies. Patients were more likely to accept adjuvant radiation than adjuvant chemotherapy.

References

Jul 1, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R A Ord, S Aisner
Aug 5, 2000·International Journal of Radiation Oncology, Biology, Physics·E P JansenH Bartelink
Mar 26, 2003·International Journal of Oral and Maxillofacial Surgery·D N SuttonJ A Woolgar
Dec 19, 2006·Oral Oncology·Abdulaziz BinahmedAhmed A Abdoh
Apr 7, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J BradleyC René Leemans
Dec 17, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Kumar Alok PathakPaul D Kerr
Jan 27, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Richard W NasonGeorge K B Sándor

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Citations

Nov 19, 2021·Frontiers in Oncology·Axel SahovalerJonathan C Irish

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