The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications

European Journal of Heart Failure
Magdalena StugiewiczEwa A Jankowska

Abstract

Skeletal and respiratory myopathy not only constitutes an important pathophysiological feature of heart failure and chronic obstructive pulmonary disease, but also contributes to debilitating symptomatology and predicts worse outcomes in these patients. Accumulated evidence from laboratory experiments, animal models, and interventional studies in sports medicine suggests that undisturbed systemic iron homeostasis significantly contributes to the effective functioning of skeletal muscles. In this review, we discuss the role of iron status for the functioning of skeletal muscle tissue, and highlight iron deficiency as an emerging therapeutic target in chronic diseases accompanied by a marked muscle dysfunction.

References

Aug 1, 1976·The Journal of Clinical Investigation·C A FinchB Mackler
May 1, 1992·Circulation·H DrexlerH Just
Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·L L Spriet
Jan 1, 1991·British Heart Journal·N P BullerP A Poole-Wilson
Feb 1, 1988·International Journal of Cardiology·D P LipkinP A Poole-Wilson
May 1, 1985·Journal of Applied Physiology·M V PerkkiöP R Dallman
Apr 1, 1986·Medicine and Science in Sports and Exercise·F CelsingB Ekblom
Sep 1, 1972·Journal of Applied Physiology·P D GollnickB Saltin
Mar 1, 1972·The Journal of Nutrition·V R EdgertonG W Gardner
Oct 1, 1984·Journal of Muscle Research and Cell Motility·M R Iyengar
Jan 1, 1981·The Journal of Nutrition·Y OhiraG A Brooks
Mar 1, 1995·The Proceedings of the Nutrition Society·E Hultman
Aug 1, 1994·British Heart Journal·A J CoatsP A Poole-Wilson
Aug 1, 1993·Journal of Internal Medicine·C H ThompsonB Rajagopalan
Mar 1, 1993·The American Review of Respiratory Disease·J F PayenJ F Le Bas
Jan 1, 1993·Acta Physiologica Scandinavica·C H ThompsonB Rajagopalan
Apr 1, 1996·Physiological Reviews·S Schiaffino, C Reggiani
Dec 18, 1997·The New England Journal of Medicine·S LevineB Tikunov
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·S BernardF Maltais
Mar 10, 2000·Journal of Applied Physiology·P S HintonJ D Haas
Jun 14, 2000·Journal of Applied Physiology·W W WinderJ O Holloszy
Aug 2, 2000·The American Journal of Clinical Nutrition·J Beard, B Tobin
Aug 26, 2000·Progress in Biophysics and Molecular Biology·R Bottinelli, C Reggiani
Oct 5, 2001·Journal of the American College of Cardiology·B MettauerR Ventura-Clapier
Mar 28, 2002·The American Journal of Clinical Nutrition·Thomas BrownlieJere D Haas
Feb 26, 2003·Revue des maladies respiratoires·A CuvelierF Chabot
Mar 1, 2003·The European Respiratory Journal·A G N AgustíX Busquets
Aug 31, 2004·Thorax·B PollaC Reggiani

❮ Previous
Next ❯

Citations

May 22, 2016·European Journal of Heart Failure·Elliott M AntmanJose L Zamorano
Jul 6, 2016·International Journal of Cardiology·Mauro GoriMichele Senni
Jul 19, 2016·European Journal of Heart Failure·Marco Metra
Aug 6, 2016·International Journal of Cardiology·Joanna BojarczukPiotr Ponikowski
Apr 4, 2017·European Journal of Heart Failure·Marco Metra
Dec 4, 2016·The American Journal of Emergency Medicine·Matthieu MarchettiNicolas Marjanovic
Mar 2, 2018·European Journal of Heart Failure·Pieter MartensWilfried Mullens
Nov 14, 2017·ESC Heart Failure·Amir EmamiStephan von Haehling
Sep 5, 2018·Journal of Cachexia, Sarcopenia and Muscle·Magdalena DziegalaEwa Jankowska
Sep 18, 2018·Journal of Cardiovascular Medicine·Elisabetta DinatoloStephan von Haehling
Dec 21, 2018·ESC Heart Failure·Elisabetta DinatoloMarco Metra
Oct 18, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Pieter A Leermakers, Harry R Gosker
May 4, 2017·Expert Review of Medical Devices·Luca BottaClaudio Francesco Russo
Aug 10, 2019·Journal of Cardiovascular Medicine·Edoardo SciattiCarlo Mario Lombardi
Mar 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pieter A LeermakersHarry R Gosker
Mar 25, 2020·Journal of Intensive Care Medicine·Matthew A WarnerDale M Needham
Jan 19, 2017·Oncotarget·Mariana Janini GomesMarina Politi Okoshi
Jun 23, 2020·BMJ Open Respiratory Research·Peter SanterPeter A Robbins
Jul 9, 2020·Sports Health·Jihoon T ChoiGeorge F Hatch
Sep 25, 2017·International Urology and Nephrology·Aslihan YerlikayaMehmet Kanbay
Jul 3, 2017·Current Heart Failure Reports·Lucas N L Van AelstAlain Cohen-Solal
May 11, 2018·International Journal of Chronic Diseases·Axel DignassJürgen Stein
Apr 10, 2019·Anaesthesia·A Shah, C R Bailey
Oct 14, 2019·Current Heart Failure Reports·Laura MurphyEmer Joyce
Apr 3, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jan WintrichMichael Böhm
Oct 5, 2018·Heart Failure Reviews·Kamil A KobakEwa A Jankowska
Apr 25, 2019·Heart Failure Reviews·Mihai LupuGabriela Adriana Filip
Jan 14, 2020·Pakistan Journal of Biological Sciences : PJBS·Samah Attia El ShemyHanan Ali Madani
Sep 10, 2020·European Journal of Clinical Nutrition·Sophia NeidleinMaryam Pourhassan
Mar 3, 2017·European Journal of Heart Failure·Marco Metra
May 21, 2019·Frontiers in Physiology·Yafeng WangChanglian Zhu
Jan 8, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Ewa A JankowskaPiotr Ponikowski
Mar 29, 2019·Circulation Reports·Yoichiro OtakiMasafumi Watanabe
Mar 26, 2021·Clinical Medicine : Journal of the Royal College of Physicians of London·Abdulrahman Al-NaseemJecko Thachil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.