The influence of isoprostanes on ADP-induced platelet aggregation and cyclic AMP-generation in human platelets

Thrombosis Research
N LeitingerH Sinzinger

Abstract

Isoprostanes are eicosanoids that are non-enzymatic products of free radical catalyzed peroxidation of arachidonyl containing phospholipids (1). They are subsequently released from the site of generation as esters of phospholipid (bound) or through the action of phospholipase(s) A2 in free form (2). One F2-isoprostane whose formation is highly favored is 8-iso-PGF2 alpha which has been shown to be a potent pulmonary and renal vasoconstrictor (3,4). Actions of 8-iso-PGF2 alpha were demonstrated to be mediated through a receptor related to but probably distinct from the thromboxane (TXA2)/endoperoxide (PGH2) receptor (5). Although 8-epi-PGF2 alpha is a potent agonist of TXA2/PGH2 receptors in vascular smooth muscle, interestingly it acts primarily as an antagonist of TXA2/PGH2 receptors on both human and rat platelets (6). There is also evidence for the generation of D- and E-ring isoprostanes (7) and their receptor-mediated action on smooth muscle cells (8) and platelets (9). Recent reports support the hypothesis that E2-isoprostane receptors are distinct from TXA2/PGH2 receptors, suggesting at least different subtypes, one of these specifically recognizing E2-isoprostanes (9). Isoprostanes have been suggested to be useful marke...Continue Reading

References

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Citations

Jan 10, 2002·Biochemical and Biophysical Research Communications·Zakaria AhmedPhilip W Connelly
Oct 25, 2003·Life Sciences·Roswitha M WolframHelmut Sinzinger
Nov 4, 2000·Prostaglandins & Other Lipid Mediators·H Junger, L S Sorkin
Apr 20, 2001·British Journal of Pharmacology·J H CranshawJ A Mitchell
Nov 13, 1998·Current Opinion in Lipidology·J L Witztum, J A Berliner
Nov 1, 2011·Thrombosis Research·Matteo Nicola Dario Di MinnoGiovanni Di Minno
Mar 29, 2014·Circulation Research·Valerie B O'DonnellSteve P Watson
Oct 13, 2005·Journal of Cardiovascular Pharmacology·Grazyna SobalH Sinzinger
Jul 19, 2003·Molecular Pharmacology·Elizabeth A Cowley
Sep 25, 2003·Physiological Reviews·Bjarne Osterud, Eirik Bjorklid
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·L J Janssen
May 15, 2009·Platelets·Barbara DołegowskaKazimierz Ciechanowski
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M G MeyerB T Nixon
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N LeitingerB R Binder

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