PMID: 9171118Jun 1, 1997Paper

The influence of laparotomy and laparoscopy on tumor growth in a rat model

Surgical Endoscopy
C A JacobiJ M Müller

Abstract

The effects of laparotomy and laparoscopy with different gases on subcutaneous and intraperitoneal tumor growth have not been evaluated yet. Tumor growth of colon adenocarcinoma DHD/K12/TRb was measured in rats after laparotomy, laparoscopy with CO2 or air, and in control group. Cell kinetics were determined after incubation with carbon dioxide or air in vitro and tumor growth was measured subcutaneously and intraperitoneally after surgery in vivo. In vitro, tumor cell growth increased significantly after incubation with air and CO2. In vivo, intraperitoneal tumor weight was increased after laparotomy (1,203 +/- 780 mg) and after laparoscopy with air (1,085 +/- 891 mg) and with CO2 (718 +/- 690 mg) compared to control group (521 +/- 221 mg) (p < 0.05). Subcutaneous tumor growth was promoted after laparotomy (71 +/- 35 mg) and even more after laparoscopy with air (82 +/- 45 mg) and CO2 (99 +/- 55 mg) compared to control group (36 +/- 33 mg). Insufflation of air and CO2 promote tumor growth in vitro. In vivo, intraperitoneal tumor growth seems to be promoted primarily by intraperitoneal air and subcutaneous tumor growth by CO2.

Citations

Nov 7, 2000·Journal of Surgical Oncology·P G Jackson, S R Evans
May 19, 2001·Surgical Endoscopy·J E HartleyJ R Monson
Jul 10, 2001·Surgical Endoscopy·T SuematsuS Kitano
Jul 27, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·F LécuruR Taurelle
Jun 8, 2001·Journal of Endourology·A CiccoC C Abbou
Mar 18, 2005·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Chandrakanth Are, Mark A Talamini
Feb 27, 1999·Current Opinion in Obstetrics & Gynecology·J M Childers
May 19, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M CanisM A Bruhat
Apr 5, 2001·Surgical Endoscopy·R L Whelan
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·A G LopesA J Rodrigues
Aug 8, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Heiko SorgBrigitte Vollmar
Jun 12, 2004·American Journal of Surgery·Myriam J Curet
May 20, 1999·The Journal of Urology·C C AbbouL Salomon
Dec 18, 2001·American Journal of Obstetrics and Gynecology·V J SmidtW W Hurd
Dec 17, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Piotr SobiczewskiWojciech Michalski
Oct 18, 2008·Expert Review of Anticancer Therapy·David A Kooby
Sep 17, 2002·Journal of the American College of Surgeons·Paul ZiprinAra W Darzi

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