The influence of leptin on early life programming of obesity

Trends in Biotechnology
Claire J Stocker, Michael A Cawthorne

Abstract

Epidemiological evidence together with experimental models shows a direct relationship between fetal and early postnatal growth patterns and an increased risk of adult metabolic disease. Maternal health and nutrition are key determinants in influencing infant growth but the precise molecular mechanisms underlying this relationship are unclear, although it is evident that there are critical time windows when these effects are important. Animal models show mechanistic parallels with human populations and highlight that the early environment represents a therapeutic window for protection from obesity and metabolic disease. The observation that developmental programming can be reversed has been demonstrated in studies in which both maternal and neonatal leptin treatment prevents the induction of the adverse metabolic phenotype. Given that orally administered peptides are absorbed intact by the new born, the prospect of providing supplemental leptin either as drops or in milk deserves serious consideration as a means of reducing or reversing the obesity and type 2 diabetes epidemic.

References

Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Jul 6, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S CintiA Palou
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R J LoosR Vlietinck
Aug 8, 2002·The Journal of Nutritional Biochemistry·Ci;ntia TeixeiraEgberto Moura
Aug 9, 2002·Nature·Michael W Schwartz, Gregory J Morton
Sep 13, 2002·Obesity Research·Catalina PicóAndreu Palou
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·Patrick M Catalano
Oct 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C StockerM A Cawthorne
Mar 3, 2004·Circulation·Atul SinghalAlan Lucas
Apr 6, 2004·Science·Sebastien G BouretRichard B Simerly
Aug 18, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S ArenzR von Kries
Oct 16, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M C PassosE G de Moura
May 10, 2005·The Proceedings of the Nutrition Society·Jonathan R S Arch
Jun 22, 2005·Clinical Science·Roselle L CrippsSusan E Ozanne
Jul 16, 2005·Endocrinology·M H VickersM Harris
Aug 4, 2005·American Journal of Epidemiology·Thomas HarderAndreas Plagemann
Nov 12, 2005·Endocrinology·Jun UdagawaHiroki Otani
Nov 18, 2005·Physiology & Behavior·Kevin L GroveM Susan Smith
Mar 31, 2006·The British Journal of Nutrition·Fabiane Pereira TosteMagna Cottini Fonseca Passos
Apr 14, 2006·Hormone Research·P D Gluckman, M A Hanson
Apr 14, 2006·Hormone Research·K K Ong
May 2, 2006·The Journal of Endocrinology·Stefan O KrechowecBernhard H Breier
Jun 15, 2006·Nutrition Reviews·Atul Singhal
Jun 28, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M LópezC Diéguez
Dec 16, 2006·Experimental Physiology·P D Taylor, L Poston
Dec 22, 2006·The British Journal of Nutrition·Jacqueline M WallaceRaymond P Aitken
Jan 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Claire J StockerMichael A Cawthorne
Mar 16, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C PicóA Palou
May 24, 2007·Diabetes Care·Teresa A HillierDavid J Pettitt

❮ Previous
Next ❯

Citations

Jan 6, 2010·International Journal of Pediatric Endocrinology·Francesco SavinoRoberto Oggero
May 7, 2011·Journal of Pregnancy·Erich CosmiVincenzo Zanardo
Dec 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Janna L MorrisonIsabella C McMillen
Jul 1, 2010·European Journal of Clinical Nutrition·F SavinoL Silvestro
Mar 4, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Xin-Yu Liu, De-Hua Wang
Oct 6, 2015·International Journal of Environmental Research and Public Health·Anna M CannonDonna T Geddes
May 30, 2012·Early Human Development·Francesco SavinoRoberto Oggero
Sep 21, 2010·Archives of Medical Research·Consuelo Treviño-GarzaJesús Argente
Jul 20, 2010·Physiology & Behavior·Ajaykumar N SharmaJames B Lucot
May 14, 2016·Metabolism: Clinical and Experimental·Polyxeni KarakostaLeda Chatzi
Oct 31, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·Elizabeth M MillerE A Quinn
Nov 28, 2012·Maternal & Child Nutrition·Zhenyu Yang, Sandra L Huffman
Mar 12, 2015·Social Work in Public Health·Elena Delavega, Robin Lennon-Dearing
Jun 14, 2014·Journal of Developmental Origins of Health and Disease·M A KępczyńskaC J Stocker
Jun 8, 2017·Paediatric and Perinatal Epidemiology·Cecilia Ponce-GarciaCarlos Flores-Mir
Mar 17, 2011·Journal of Pediatric Gastroenterology and Nutrition·Jiri BronskyJiri Nevoral
Jul 7, 2016·American Journal of Physiology. Endocrinology and Metabolism·Charline QuicletKarine Couturier
May 1, 2020·Journal of Developmental Origins of Health and Disease·D SamaranayakeV P Wickramasinghe
Nov 1, 2009·Expert Review of Endocrinology & Metabolism·Margaret J Morris
May 5, 2016·Endocrinology·Omonseigho O TaltonLaura C Schulz
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Dec 13, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Jana BuresovaJan Kopecky
Jul 10, 2019·Nutrición hospitalaria·Alfredo Larrosa HaroEnrique Romero-Velarde
May 6, 2011·The American Journal of Clinical Nutrition·Catalina PicoJan Kopecky
Oct 2, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Claudia G LiberiniMatthew R Hayes
Aug 9, 2019·International Journal of Obesity Supplements·Giovanni SarnelliUNKNOWN Obesity Programs of nutrition, Education, Research and Assessment (OPERA) group
Nov 10, 2018·Metabolism: Clinical and Experimental·Ling-Jun LiEmily Oken

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.