PMID: 2508078Jul 1, 1989Paper

The influence of liposomal encapsulation on sodium cromoglycate pharmacokinetics in man

Pharmaceutical Research
K M TaylorJ Stevens

Abstract

The pharmacokinetics of pulmonary-administered sodium cromoglycate (SCG) has been studied in five healthy volunteers. SCG, 20 mg, was inhaled as a solution and encapsulated in dipalmitoyl phosphatidylcholine/cholesterol (1:1) liposomes. Liposomal SCG produced detectable drug levels in plasma from four volunteers taken 24 and 25 hr after inhalation. Inhaled SCG solution, although producing peak plasma levels more than sevenfold greater than liposomal drug, was not detectable in 24-hr samples from any volunteer. The decline in plasma levels following inhalation of liposomal SCG (reflecting the absorption phase) was best described by a biexponential equation. The two absorption rate constants differed by more than an order of magnitude. The rapid absorption phase was probably due to free or surface-adsorbed SCG in the liposomal formulation, since the absorption rate constant for this phase did not differ significantly from the absorption rate constant for SCG in solution. The phase of slow drug absorption may then be attributed to absorption of drug released from vesicles. The data indicate that encapsulation of SCG prior to pulmonary administration prolonged drug retention within the lungs and altered its pharmacokinetics.

Citations

Jan 1, 1991·The Journal of Pharmacy and Pharmacology·M Jurima-Romet, P N Shek
Jan 1, 1993·Journal of Microencapsulation·M SinghM Mezei
May 9, 2009·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jeffry WeersWalter R Perkins
May 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Q A Summers
Jun 30, 2006·The Journal of Pharmacy and Pharmacology·Abdelbary M A ElhissiKevin M G Taylor
Oct 18, 2008·Journal of Microencapsulation·Aileen M GibbonsSally-Ann Cryan
Aug 1, 1995·Anesthesiology·O R HungM Mezei
Jan 15, 1999·Journal of Drug Targeting·Z E Suntres, P N Shek
Jan 1, 1993·Experimental Lung Research·M A MyersR J Gonzalez-Rothi
Aug 6, 2010·Journal of Liposome Research·Abdelbary ElhissiKevin Taylor
Aug 8, 2013·Therapeutic Delivery·David CipollaHak-Kim Chan
Apr 1, 1992·Thorax·K M Taylor, J M Newton
Mar 6, 2008·Expert Opinion on Drug Delivery·Yuanyuan XieTimothy S Wiedmann
Feb 20, 2020·Expert Opinion on Drug Delivery·Ali KeshavarzFakhrul Ahsan
Feb 26, 2021·International Journal of Nanomedicine·Hongfei XuJingling Tang

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