PMID: 15338588Sep 2, 2004Paper

The influence of lithium fluoride on in vitro biocompatibility and bioactivity of calcium aluminate-pMMA composite cement

Journal of Materials Science. Materials in Medicine
S H OhK N Kim

Abstract

The objective of this study is to assess the influence of lithium fluoride on in vitro biocompatibility and bioactivity of calcium aluminate (CA)-polymethylmethacrylate (PMMA) composite cement exhibiting quick setting time ( < 15 min), low exothermic temperature (< 47 degrees C), and high compressive strength (> 100 MPa). The biocompatibility was measured by examining cytotoxicity tests such as the agar diffusion test with L929 cell line and the hemolysis test with fresh rabbit blood. To estimate the bioactivity of CA-PMMA composite cement, we determined hydroxyapatite (HAp) formation on the surface of composite cement in the simulated body (SBF) solution by using thin-film XRD, XPS, SEM, EPMA and ICP-AES. The results of biocompatibility tests indicated that all experimental compositions of this study had no cytotoxicity and no hemolysis so that there was no cytotoxicity with regard to non-reacted monomers (MMA and TEGDMA) and lithium fluoride. The results of bioactivity tests revealed that CA-PMMA composite cement without lithium fluoride did not form HAp on its surface after 60 days of soaking in the SBF. On the other hand, LiAl2(OH)7 . 2H2O and HAp were formed on the surface of CA-PMMA composite cement including 1.0% by weig...Continue Reading

Citations

Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Yue SaJohn A Jansen
Jun 24, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yue SaYining Wang
Aug 17, 2005·Biomaterials·Jorrit-Jan VerlaanWouter J A Dhert
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·I O Acuña-GutiérrezA Zugasti-Cruz
Nov 7, 2009·Brazilian Oral Research·Ricardo Carneiro BorraPriscila Maria Andrade
Jul 22, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Su-Hee LeeYoung-Il Chang

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