The influence of major dietary fatty acids on insulin secretion and action

Current Opinion in Lipidology
Sergio LópezFrancisco J G Muriana

Abstract

To briefly summarize recent advances towards understanding the influence of major dietary fatty acids on beta-cell function and evaluate their implications for insulin resistance. Studies in humans have shown that beta-cell function and insulin sensitivity improve progressively in the postprandial period as the proportion of monounsaturated fatty acids (MUFAs) with respect to saturated fatty acids (SFAs) in dietary fats increases. However, cell-culture experiments have revealed a dichotomy in the ability of fatty acids to moderate hyperactivity of, and induce lipotoxicity in, beta-cells. There are also some novel findings regarding the ability of HDL to protect beta-cells against oxidized LDL-induced apoptosis in vitro and of reconstituted HDL to attenuate insulin resistance in vivo. These findings raise new questions regarding the contribution of dietary fatty acids to insulin secretion and action. These new findings point to a critical role for major dietary fatty acids in the etiology and pathogenesis of diabetes, which appears to be of particular relevance during postprandial periods and mainly depends on the fatty acid type. This underscores the importance of dietary fatty acids in standard diabetes management.

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Citations

Mar 16, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Brian T LaydenWilliam L Lowe
Jan 27, 2016·Nutrition Research Reviews·Aishwarya KumarMartin R Lindley
Jan 28, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Priya HandaKris V Kowdley
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Sep 30, 2017·Journal of the Science of Food and Agriculture·Sergio Montserrat-de la PazFrancisco Jg Muriana
Jul 18, 2017·BMJ Open Diabetes Research & Care·Miguel Ángel Gómez-SámanoFrancisco J Gómez-Pérez
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Nov 26, 2010·Current Opinion in Lipidology·Arnold von Eckardstein, Rahel A Sibler
Apr 11, 2018·Oxidative Medicine and Cellular Longevity·Karamat MohammadVladimir I Titorenko

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