PMID: 9638715Jun 25, 1998Paper

The influence of mannitol on renal function during and after open-heart surgery

Perfusion
A R FisherM Yacoub

Abstract

Mannitol is often included in the priming solution of the heart-lung machine used during cardiopulmonary bypass (CPB). This study was set up to evaluate the effect of different doses of mannitol on human patients. Patients receiving 10 g of mannitol (n = 18) had an increased diuresis only during the bypass period (mean time = 87 min) when compared with a control group (n = 19) who did not receive mannitol. Patients receiving 20 g of mannitol (n = 19) had a significantly greater diuresis than both the control group and the 10 g group and the diuresis continued on throughout the immediate postbypass period (total mean time approximately 3 h). Patients receiving 30 g of mannitol (n = 20) also had a significantly greater diuresis that continued on during the first hour in the intensive care unit (ICU) (total mean time approximately 4 h). After 6 h in the ICU, all three groups of mannitol-treated patients equally demonstrated a trend towards an increased diuresis over the control group, which became a significant increase by 12 h in the ICU (p = 0.001) despite indications that the mannitol had been cleared from the body. These results suggest that there is an improvement of renal function post-CPB if mannitol is included in the CPB ...Continue Reading

Associated Clinical Trials

Mar 24, 2015·Eduesley Santana Santos

References

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Citations

Nov 28, 2012·Journal of Anesthesia·Satyen Parida, Ashok Shankar Badhe
Apr 21, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Pradeep AroraJames Lohr
Jun 21, 2008·Advances in Chronic Kidney Disease·Mark Stafford-SmithMadhav Swaminathan
Mar 2, 2011·Asian Cardiovascular & Thoracic Annals·Sharon H L ChuYuki Watanabe
Dec 15, 2015·Seminars in Cardiothoracic and Vascular Anesthesia·Gary LauC David Mazer
Jan 31, 2008·Journal of Intensive Care Medicine·Mitchell H RosnerMark D Okusa
Mar 1, 2005·Seminars in Cardiothoracic and Vascular Anesthesia·Mark Stafford-Smith
Oct 16, 2016·Seminars in Cardiothoracic and Vascular Anesthesia·Matthew S MoscaT Brett Reece
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Mitchell H Rosner, Mark D Okusa
Nov 8, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Robert H ThieleMitchell H Rosner
Sep 13, 2013·The Cochrane Database of Systematic Reviews·Mathew ZachariasNiamh P Conlon
Jul 10, 2019·Acta Anaesthesiologica Scandinavica·Magnus LjunggrenSnejana Hyllén
Nov 8, 2011·Journal of the American Animal Hospital Association·Richard BednarskiUNKNOWN American Animal Hospital Association
Jul 5, 2006·Perfusion·Líney SímonardóttirJónas Magnússon

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