PMID: 2504900Jun 1, 1989Paper

The influence of melanins on the photoperoxidation of lipids

Journal of Photochemistry and Photobiology. B, Biology
A Ezzahir

Abstract

The influence of synthetic Dopa-melanin, natural-A, AB-melanin and pheomelanin has been studied for the following processes: (1) microsomal and liposomal lipid peroxidation induced by illumination with UV- and visible light; (2) interaction of melanin with the superoxide anion; and (3) chemiluminescence intensity of phospholipids in the presence and absence of melanins. It has been shown that (a) melanins can function as a scavenger of the superoxide anion radical O2-. (pseudo-superoxide dismutase) and (b) melanins protect microsomes and liposomes against lipid peroxidation which is due to the absorption of light energy (filter effect). Our data show that in the presence of melanins lipid peroxidation is significantly lower in comparison with the phospholipids incubated in the absence of melanins (except pheomelanin). The level of photoperoxidation of lipids was studied by means of the chemiluminescence method and by measurement of the malondialdehyde product. The results obtained by both methods indicate that melanin can effectively influence the process of lipid peroxidation. Mechanisms involved in the physical (optical screening) and photochemical reactions are proposed.

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Citations

Sep 6, 2001·Journal of Photochemistry and Photobiology. B, Biology·S M De LeeuwA A Schothorst
May 17, 1997·Biochimica Et Biophysica Acta·S MemoliG Prota
Dec 24, 1997·The Journal of Investigative Dermatology·N P SmitS Pavel
Jun 26, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S PageA Baranova
Oct 12, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J E WikbergA Skottner
Jul 20, 2001·Current Eye Research·K Nau-StaudtJ Flammer
Oct 27, 2004·Photochemistry and Photobiology·Yan LiuJohn D Simon
Dec 27, 2017·Current Medicinal Chemistry·Ioana BaldeaGabriela Adriana Filip
Dec 22, 1998·Chemical Research in Toxicology·E S Krol, D C Liebler
Dec 8, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fabio MollicaRiccardo Amorati

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