The influence of melatonin on the content of vasopressin and oxytocin in the hypothalamus and neurohypophysis in euhydrated and dehydrated male rats

Journal of Pineal Research
M JuszczakA Lewy

Abstract

Melatonin injected in a single intraperitoneal dose of 100 micrograms/100 g b.w. to euhydrated rats resulted in a decrease of neurohypophysial oxytocin content but the hypothalamic oxytocin storage as well as the hypothalamo-neurohypophysial storage of vasopressin were not changed. Following 8 d of once-daily melatonin treatment the hypothalamic and neurohypophysial oxytocin and vasopressin content was decreased. It might be therefore suggested that melatonin increases the release of neurohypophysial hormones and/or decreases their synthesis. Melatonin did not significantly modify the neurohypophysial vasopressin depletion rate in animals deprived of water up to 8 days. No consistent effects of melatonin on the decrease of hypothalamo-neurohypophysial content of oxytocin were noted under conditions of dehydration and simultaneous administration of melatonin up to 8 d.

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Citations

Jan 1, 1997·Brain Research Bulletin·M Juszczak, B Stempniak
Nov 18, 2000·Proceedings of the Society for Experimental Biology and Medicine·M JuszczakR Dabrowski
Jan 1, 1992·Journal of Pineal Research·M JuszczakJ W Guzek
Mar 24, 1998·Clinical Endocrinology·I Kostoglou-AthanassiouM L Forsling
Dec 14, 1999·Clinical Endocrinology·M L ForslingA J Williams

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