The influence of metabolic inhibitors upon the transmembrane slow inward current in the mammalian ventricular myocardium.

Naunyn-Schmiedeberg's Archives of Pharmacology
M Kohlhardt, M Kübler

Abstract

The effect of metabolic alterations of isolated trabeculae and papillary muscles of cats upon the transmembrane slow inward current was studied in voltage clamp experiments using the double sucrose gap technique. The slow inward current which is mainly carried by Ca ions was separated from the fast Na current by applying the conditioning clamp technique. 1. After inhibition of the oxidative phosphorylation of the myocardial cell caused by cyanide (100 mg/l), the transmembrane slow inward current decreased by 25% on average within 25 min. The same diminution appeared after poisoning with 2.4 dinitrophenol (40 mg/l) which amounted to 46% on an average. In both cases the extrapolated reversal potential of the slow inward current was shifted to less positive values. The reduction of the slow inward current seems to reflect a diminished Ca driving force due to a metabolically evoked increase in intracellular free Ca. But these metabolic inhibitors might exert some direct effects upon the membrane since after the treatment with cyanide and 2.4 dinitrophenol, respectively, a slight delay of current inactivation could be observed. Nevertheless, the kinetics of the recovery from inactivation remained unaffected. 2. Metabolic poisoning a...Continue Reading

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Dec 1, 1994·Cardiovascular Drugs and Therapy·R N Gasser, W Klein
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R Volkmann, A S Pettersson
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May 1, 1978·Circulation Research·E Carmeliet

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