The influence of microenvironment on tumor immunotherapy

The FEBS Journal
Jieying ZhangJun Mi

Abstract

Tumor immunotherapy has achieved remarkable efficacy, with immune-checkpoint inhibitors as especially promising candidates for cancer therapy. However, some issues caused by immunotherapy have raised attention, such as limited efficacy for some patients, narrow antineoplastic spectrum, and adverse reactions, suggesting that using regulators of tumor immune response may prove to be more complicated than anticipated. Current evidence indicates that different factors collectively constituting the unique tumor microenvironment promote immune tolerance, and these include the expression of co-inhibitory molecules, the secretion of lactate, and competition for nutrients between tumor cells and immune cells. Furthermore, cancer-associated fibroblasts, the main cellular components of solid tumors, promote immunosuppression through inhibition of T cell function and extracellular matrix remodeling. Here, we summarize the research advances in tumor immunotherapy and the latest insights into the influence of microenvironment on tumor immunotherapy.

References

May 4, 1999·The Journal of Experimental Medicine·D H MunnA L Mellor
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hedi HariziNorbert Gualde
Apr 22, 2003·Journal of Cellular Physiology·Angel Garcia-LoraFederico Garrido
Jul 10, 2003·Immunology and Cell Biology·John R Moffett, Ma Aryan Namboodiri
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paulo C RodriguezAugusto C Ochoa
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L MellorDavid H Munn
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuharu AkasakiJohn S Yu
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Candace M Cham, Thomas F Gajewski
May 4, 2005·Cancer Research·Birgitte Grum-SchwensenNoona Ambartsumian
Oct 18, 2005·Molecular and Cellular Biology·Richard V ParryJames L Riley
Oct 7, 2006·Blood·Paulo C RodriguezAugusto C Ochoa
Jan 27, 2007·Blood·Karin FischerMarina Kreutz
Jul 25, 2008·Nature·Ruslan Medzhitov
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Sep 16, 2008·European Journal of Immunology·Candace M ChamThomas F Gajewski
Dec 26, 2008·Haematologica·Muzlifah A HaniffaFrancesco Dazzi
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Mar 13, 2009·Nature Reviews. Cancer·Johanna A Joyce, Jeffrey W Pollard
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
May 28, 2009·Cell Cycle·George C PrendergastAlexander J Muller
Aug 26, 2009·The Journal of Experimental Medicine·Akihiro KimuraTadamitsu Kishimoto
Sep 23, 2009·Annals of the New York Academy of Sciences·Andrew J Rech, Robert H Vonderheide
Jan 29, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brett C DiNataleGary H Perdew
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jul 31, 2010·Molecular Cell·Katrin DüvelBrendan D Manning
Sep 8, 2010·The New England Journal of Medicine·Philip W KantoffUNKNOWN IMPACT Study Investigators
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nam Trung NguyenTadamitsu Kishimoto
Jul 29, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jermaine CowardFrances R Balkwill
Sep 8, 2011·International Journal of Cancer. Journal International Du Cancer·Anna N MendlerElfriede Noessner
Sep 17, 2011·Journal of the American Chemical Society·Cheryl L StrelkoMary F Roberts
Nov 9, 2011·Cancer Research·Hagen KulbeFrances R Balkwill
Dec 7, 2011·Critical Reviews in Immunology·Muhammad Zaeem NomanSalem Chouaib
Mar 13, 2012·Cancer Discovery·Sergey V NovitskiyHarold L Moses
Mar 24, 2012·Cancer Cell·Patrick S Ward, Craig B Thompson
Apr 5, 2012·International Immunology·Clarissa Anni WildStephan Lang
May 18, 2012·Science Translational Medicine·Andrew J RechRobert H Vonderheide
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Eric T ClambeyHolger K Eltzschig
Nov 10, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Clara PåhlmanHenrik Ekberg
Feb 20, 2013·International Journal of Cancer. Journal International Du Cancer·Toshimitsu OhashiNorimitsu Inoue

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Citations

Sep 11, 2020·Journal of Cellular and Molecular Medicine·Zhenxing WangFengwu Lin
May 8, 2020·Nuclear Medicine and Molecular Imaging·Niklaus SchaeferMargret Schottelius
Oct 11, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Colby S ShemeshBenjamin Wu
Oct 29, 2020·Cancer Gene Therapy·Jonathan BrionesMasato Saito
Mar 5, 2021·Cancer Immunology, Immunotherapy : CII·Xian-Ning WuNan Zhang
May 1, 2021·Biomedicines·Melanie A KimmMoritz Wildgruber
Jul 17, 2021·Journal of Cellular and Molecular Medicine·Yibei WangYun Han

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BETA
xenograft
nuclear translocation

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