The influence of mineral trioxide aggregate on adaptive immune responses to endodontic pathogens in mice.

Journal of Endodontics
Taia Maria Berto RezendeToshihisa Kawai

Abstract

This study assessed the influence of mineral trioxide aggregate (MTA) on adaptive immune responses. BALB/c mice were immunized with heat-killed Fusobacterium nucleatum (Fn) in MTA or other control adjuvants, and serum IgG responses to Fn were measured. Either Fn- or Peptostreptococcus anaerobius (Pa)-reactive memory T cells (Tm) were preincubated in vitro with/without MTA and restimulated with Fn or Pa. Tm proliferation and cytokine production were assessed. Compared with control groups, immunoglobulin G-antibody responses were upregulated in mice immunized with Fn in MTA in a similar manner to animals immunized with Fn in Freund's adjuvant or aluminum hydroxide adjuvant. Although MTA did not affect the upregulated expression of interleukin 10, tumor necrosis factor alpha, or RANKL by Tm, it suppressed the proliferation of Pa- or Fn-Tm and inhibited their production of Th1- or Th2-signature cytokines. MTA upregulated the adaptive humoral immune responses but had little or no effect on pro- or anti-inflammatory cytokine production by Tm.

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Citations

Nov 24, 2012·Dental Clinics of North America·Nestor CohencaJoel Berg
Mar 1, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·B W Darvell, R C T Wu
Apr 27, 2010·Journal of Endodontics·Shahriar ShahiMajid Abdolrahimi
May 4, 2011·International Endodontic Journal·C C ChenS J Ding
Jun 16, 2015·International Endodontic Journal·L KarygianniM J Altenburger
Aug 28, 2015·Brazilian Dental Journal·Viviane de Paula Lima LaraTaia Maria Berto Rezende
May 8, 2018·International Endodontic Journal·R R OliveiraA P Ribeiro Sobrinho
Oct 18, 2018·Brazilian Oral Research·Marcela Carvalho EspaladoriAntônio Paulino Ribeiro Sobrinho

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