PMID: 8961157Nov 1, 1996Paper

The influence of moisture content on the consolidation properties of hydroxypropylmethylcellulose K4M (HPMC 2208)

The Journal of Pharmacy and Pharmacology
A NokhodchiM H Rubinstein

Abstract

The effect of moisture content, compression speed and compression force on the compaction properties of HPMC K4M has been evaluated. As the moisture content increased from 0 to 14.9% w/w, the thickness of HPMC K4M compacts increased at constant compression force and speed. This increase in moisture content also resulted in a marked increase in the tensile strength of the tablets. At a speed of 15 mm s-1 and force of 10 kN, as the moisture content increased from 0 to 14.9% w/w, the tensile strengths increased from 1.34 to 8.54 Mpa. Equivalent tensile strengths could be obtained with less compression force as the moisture content in the polymer was increased. Increasing the compression speed generally decreased the tensile strength of HPMC K4M tablets. The dependence of tablet porosity and tensile strength on compression speeds showed that HPMC K4M is consolidated by plastic deformation. At all compression speeds, an increase in moisture content reduced the percentage elastic recovery of HPMC compacts due to greater tablet consolidation. The lowest elastic recovery (1.18%) was found for tablets made at 15 mm s-1 and 5 kN, containing 14.9% w/w moisture content.

References

Mar 1, 1989·The Journal of Pharmacy and Pharmacology·N A Armstrong, L P Palfrey
May 1, 1970·Journal of Pharmaceutical Sciences·J T Fell, J M Newton
Jan 1, 1983·The Journal of Pharmacy and Pharmacology·S Malamataris, N Pilpel

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Citations

Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C Alvarez-LorenzoA Concheiro
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C Wu, J W McGinity
Nov 1, 1996·The Journal of Pharmacy and Pharmacology·A NokhodchiM H Rubinstein
Dec 1, 2005·Drug Development and Industrial Pharmacy·M L VuebaMaria Eugénia Pina
Oct 20, 2012·Drug Development and Industrial Pharmacy·Faiezah A A MohamedAli R Rajabi-Siahboomi
Nov 3, 2006·Journal of Pharmaceutical Sciences·Noha ElkhiderSergei G Kazarian
May 26, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Filip KiekensJean Paul Remon
Apr 21, 2016·Drug Development and Industrial Pharmacy·Peter GrdešičIlija Ilić
May 20, 2005·The Journal of Pharmacy and Pharmacology·Chi L LiMatthew Roberts
Nov 9, 2020·AAPS PharmSciTech·Athira R NairSwapnil J Dengale
May 1, 1997·Journal of Pharmaceutical Sciences·A NokhodchiM H Rubinstein

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