The influence of motor asymmetry on cognitive functions in Parkinson's disease

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
I I Coloman, A Sh Chimagomedova

Abstract

The asymmetry of motor symptoms in Parkinson's disease (PD) reflects the asymmetry of the degenerative process and death of nigrostriatal dopaminergic neurons in the substantia nigra, which is confirmed by the data of functional neuroimaging. This review discusses a possible effect of the asymmetry of substantia nigra lesions on other PD symptoms, primarily neuropsychological functions. The authors summarize the data obtained in a comparative analysis of cognitive impairments in PD patients with right-sided and left-sided predominance of motor symptoms. The association between the asymmetry of motor and cognitive symptoms indicates the variability of the profile of cognitive impairments in PD, as well as an important modulating role of subcortical structures on neuropsychological functions traditionally referred to as cortical. The effect of lateralization of symptoms on cognitive function should be considered when evaluating and treating PD patients.

References

Jan 1, 1995·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·R M MariéJ C Baron
Mar 17, 2000·Brain Research. Brain Research Reviews·F A Middleton, P L Strick
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Virginia MacDonald, Glenda M Halliday
Mar 5, 2003·Medical Hypotheses·M Fritzsche
Apr 5, 2003·Journal of Neurochemistry·Ann D CohenMichael J Zigmond
Feb 24, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Cory TothAli H Rajput
May 1, 2004·Bipolar Disorders·Michael P CaligiuriJames B Lohr
Jan 26, 2005·Annals of Neurology·Rudie KortekaasN Harry Hendrikse
Aug 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·A L CheesmanD J Brooks
Aug 18, 2006·Lancet Neurology·Ruth DjaldettiEldad Melamed
Sep 17, 2008·Parkinsonism & Related Disorders·C A CooperH H Fernandez
Dec 17, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Esther CuboUNKNOWN ELEP Group Members
Nov 28, 2012·Parkinsonism & Related Disorders·Roberto ErroMaria Teresa Pellecchia
Jan 29, 2013·Medicina clínica·Jie ShiQiumin Qu
Oct 10, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Christian R BaumannDaniel Waldvogel
Dec 1, 2016·Dementia and Neurocognitive Disorders·Jee Eun YoonMoo-Young Ahn

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