The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study

Computer Methods in Biomechanics and Biomedical Engineering
Peter J WatsonCatherine A Dobson

Abstract

Remodelling and adaptation of bone within the pelvis is believed to be influenced by the mechanical strains generated during locomotion. Variation in the cortical bone thickness observed in the prenatal ilium has been linked to the musculoskeletal loading associated with in utero movements; for example the development of a thicker gluteal cortex is a possible response to contractions of the gluteal muscles. This study examines if the strains generated in the prenatal iliac cortex due to musculoskeletal loading in utero are capable of initiating bone remodelling to either maintain homeostasis or form new bone. Computational modelling techniques were used firstly to predict the muscle forces and resultant joint reaction force acting on the pelvis during a range of in utero movements. Finite element analyses were subsequently performed to calculate the von Mises strains induced in the prenatal ilium. The results demonstrated that strains generated in the iliac cortex were above the thresholds suggested to regulate bone remodelling to either maintain homeostasis or form new bone. Further simulations are required to investigate the extent to which the heterogeneous cortex forms in response to these strains (i.e., remodelling) or if ...Continue Reading

References

Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·L RookR Macchiarelli
Jan 5, 2000·Bone·R B Martin
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y F Hsieh, C H Turner
Aug 24, 2001·Pediatric Research·F Rauch, E Schoenau
Sep 7, 2001·Journal of Elasticity·G YangS C Cowin
Nov 13, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Harold M Frost
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sandra J Shefelbine, Dennis R Carter
Sep 12, 2006·Journal of Human Evolution·Timothy M Ryan, Gail E Krovitz
Apr 21, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L J SalomonY Ville
Feb 19, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Christof Land, Eckhard Schoenau
Nov 21, 2008·Journal of Anatomy·Craig A Cunningham, Sue M Black
Jun 23, 2009·Journal of Anatomy·Craig A Cunningham, Sue M Black
Jun 25, 2009·Journal of Anatomy·Craig A Cunningham, Sue M Black
Jul 29, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Craig A Cunningham, Sue M Black
Mar 9, 2011·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·P J WatsonC A Dobson
Jul 3, 2013·Annals of Biomedical Engineering·Liqiang DongKing H Yang
Mar 26, 2016·Frontiers in Pediatrics·Gyuyoup KimEung-Kwon Pae
Jan 26, 2018·Journal of the Royal Society, Interface·Stefaan W VerbruggenNiamh C Nowlan
Feb 9, 2018·Computer Methods in Biomechanics and Biomedical Engineering·Manuel da Silva PinheiroMichael Fagan

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