Feb 1, 1976

The influence of neuroleptic drugs on urinary excretion of non-protein nitrogen (author's transl)

Arzneimittel-Forschung
E Gründig, J Weiss

Abstract

During treatment with thioxanthenes or phenothiazines of schizophrenic patients non-protein nitrogen in urine was measured. The values were calculated in relation to the excretion of creatinine. a) Flupentixol or fluphenazine applied in optimal dosage, increased the excretion of urea and the amino acids asp, glu + gln, and gly. b) Moreover, if the drug induced a parkinsonoid (thioridazine) the excretion of ser and thr was increased, too. The usual desalting procedure by ion-exchanging resins before chromatography increases the contents of several amino acids, e.g. asp, asn, ala, gly, cys, ser, thr, indicating a breakdown of some instable products.

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Mentioned in this Paper

Creatinine
Schizophrenia
Controlled-Release Preparations
Phenothiazine
Carmol
Amino Acids, I.V. solution additive
Chromatography
Lyogen
Fluanxol
Antipsychotic Agents

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