PMID: 9194145May 1, 1997Paper

The influence of nicardipine and ifenprodil on the brain free arachidonic acid level and behavior in hypoxia-exposed rats

Progress in Neuro-psychopharmacology & Biological Psychiatry
V ErakovićJ Varljen

Abstract

1. The effects of the calcium channel blockers, nicardipine and ifenprodil, on the brain free arachidonic acid level and learning ability in rats exposed to hypoxia were examined. 2. Adult rats were injected with 0.003; 0.01; 0.03; 0.1; 0.3 or 1.0 mg/kg of tested drugs i.p. Thirty min later the learning ability was tested in a passive avoidance task according to the step-through procedure. Immediately after the training trial, the animals were subjected to a period of oxygen deprivation hypoxia until the loss of the righting reflex. The retention trial was carried out 24 hr later. 3. The other groups of animals were pretreated with mentioned substances before hypoxia-exposure. Fifteen min after the loss of the righting reflex they were decapitated and brains were frozen in liquid nitrogen. The brain free arachidonic acid level was quantified by gas chromatography. 4. Both nicardipine and ifenprodil were effective in preventing a memory decline in hypoxia-exposed rats but did not prevent the accumulation of the brain free arachidonic acid in hypoxia-exposed rats. 5. The protective effects of both substances in behavioral studies during acute brain damage caused by hypoxia could not be explained by the prevention of the increase ...Continue Reading

References

Jul 1, 1990·Journal of Neurochemistry·T Shimizu, L S Wolfe
Nov 1, 1990·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·T Simmet, B A Peskar
Jul 1, 1989·Brain Research. Brain Research Reviews·F B Meyer
Dec 1, 1988·Journal of Neurochemistry·D E Pellegrini-GiampietroF Moroni
Feb 1, 1987·Annals of Neurology·J C GrottaC Reich
Aug 1, 1967·Psychological Reports·M E Jarvik, R Kopp
Jan 1, 1994·European Journal of Pharmacology·K HashimotoE D London
Jan 24, 1994·European Journal of Pharmacology·S GenedaniA Bertolini
Jan 1, 1994·Annals of Neurology·L L Dugan, D W Choi

❮ Previous
Next ❯

Citations

Aug 23, 2002·European Journal of Pharmacology·Przemyslaw MikolajczakJoanna Gebka
Mar 11, 2000·Neuroscience Research·V ErakovićA Simonić
Apr 14, 2000·Brain Research. Molecular Brain Research·V ErakovićA Simonić
Oct 6, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·G ZupanJ Varljen
May 5, 2000·Fundamental & Clinical Pharmacology·D Napiórkowska-PawlakM Göthert
Feb 16, 2013·Free Radical Biology & Medicine·Shane Rowley, Manisha Patel
Oct 24, 2009·Epilepsy Research·Simon Waldbaum, Manisha Patel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.