The Influence of Nicotinamide on Health and Disease in the Central Nervous System

International Journal of Tryptophan Research : IJTR
Rosemary A FrickerSíle M Griffin

Abstract

Nicotinamide, the amide form of vitamin B3 (niacin), has long been associated with neuronal development, survival, and function in the central nervous system (CNS), being implicated in both neuronal death and neuroprotection. Here, we summarise a body of research investigating the role of nicotinamide in neuronal health within the CNS, with a focus on studies that have shown a neuroprotective effect. Nicotinamide appears to play a role in protecting neurons from traumatic injury, ischaemia, and stroke, as well as being implicated in 3 key neurodegenerative conditions: Alzheimer's, Parkinson's, and Huntington's diseases. A key factor is the bioavailability of nicotinamide, with low concentrations leading to neurological deficits and dementia and high levels potentially causing neurotoxicity. Finally, nicotinamide's potential mechanisms of action are discussed, including the general maintenance of cellular energy levels and the more specific inhibition of molecules such as the nicotinamide adenine dinucleotide-dependent deacetylase, sirtuin 1 (SIRT1).

References

Mar 1, 1990·Journal of Neurochemistry·A H SchapiraC D Marsden
Sep 29, 1989·Biochemical and Biophysical Research Communications·Y MizunoY Kagawa
Jan 1, 1987·Neurochemical Research·R Spector
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·A S MandirT M Dawson
Oct 25, 2000·Experimental Brain Research·A MeldrumS B Dunnett
Dec 29, 2000·Diabetologia·M KnipUNKNOWN European Nicotinamide Diabetes Intervention Trial Group
Jul 19, 2001·Journal of Neural Transmission·M RainerK A Jellinger
May 3, 2003·Neuroscience Letters·Richard B ParsonsDavid B Ramsden
May 28, 2003·Trends in Pharmacological Sciences·Kenneth Maiese, Zhao Zhong Chong
Jul 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·M C MorrisN Aggarwal
Aug 18, 2004·Science·Antonio Bedalov, Julian A Simon
Jan 11, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Adrian C Williams, David B Ramsden
Feb 25, 2005·QJM : Monthly Journal of the Association of Physicians·A C WilliamsD B Ramsden
Sep 27, 2005·Parkinsonism & Related Disorders·Adrian Williams, David Ramsden
Dec 20, 2005·Lancet·Cleusa P FerriUNKNOWN Alzheimer's Disease International
Aug 19, 2006·Journal of Alzheimer's Disease : JAD·Martha Clare MorrisChristine C Tangney
Mar 18, 2008·Nature Cell Biology·Timour ProzorovskiOrhan Aktas
Apr 12, 2008·Purinergic Signalling·Friedrich HaagFriedrich Koch-Nolte
Aug 16, 2008·The European Journal of Neuroscience·D W AndersonJ S Schneider
Nov 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kim N GreenFrank M LaFerla
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexandra M Nicholson, Adriana Ferreira
Aug 14, 2009·Neurobiology of Aging·Tim VanmierloMonique Mulder
Mar 13, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sherry M ZakharyGerman Torres
Mar 30, 2010·Annual Review of Neuroscience·Michael P Coleman, Marc R Freeman
Mar 23, 2009·International Journal of Tryptophan Research : IJTR·Dawn M RichardDonald M Dougherty
Dec 15, 2010·Biochemical and Biophysical Research Communications·Yun ZhangMin Deng
Apr 27, 2011·Current Medicinal Chemistry·H N JayaramJ A Yalowitz
Aug 10, 2011·Journal of the Neurological Sciences·Nikoletta SzabóLaszló Vécsei
Jan 11, 2012·The Journal of Cell Biology·Jack T WangBen A Barres

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Citations

Apr 23, 2019·Expert Opinion on Emerging Drugs·Nikolaos Giagkou, Maria Stamelou
Oct 11, 2019·Animals : an Open Access Journal From MDPI·Laura Patricia Valdez-Arjona, Mónica Ramírez-Mella
Jan 24, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Mette M Berger
May 31, 2020·Antioxidants·Mareike ZwillingVeronika Matschke
Jan 15, 2020·Current Pharmaceutical Design·Octavio Binvignat, Jordi Olloquequi
Jul 2, 2020·Journal of Biochemical and Molecular Toxicology·Jayant PatwaGopabandhu Jena
Nov 21, 2019·Current Drug Targets·Gülcem Altinoglu, Terin Adali
Sep 11, 2020·Clinical & Experimental Ophthalmology·Anna Galanopoulos, Justine R Smith
Oct 7, 2019·Metabolomics : Official Journal of the Metabolomic Society·Seon Beom SongEun Seong Hwang
Dec 19, 2018·Biochemical Society Transactions·Mikhail V MakarovMarie E Migaud
Sep 22, 2019·International Journal of Molecular Sciences·Banabihari GiriChandramohan Wakade
Nov 23, 2019·International Journal of Molecular Sciences·Rita Moretti, Costanza Peinkhofer
Apr 5, 2020·Biomolecules·Ilias P NikasHan Suk Ryu
Nov 19, 2019·Frontiers in Cellular and Infection Microbiology·Clement Gascua Adu-GyamfiMelinda Shelley Suchard
Jul 14, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Tong LiuWeisheng Feng
Jun 13, 2020·Frontiers in Neuroscience·B KuraszkiewiczM de Carvalho
Mar 1, 2019·International Journal of Molecular Sciences·Valeria GasperiMaria Valeria Catani
May 20, 2020·Antioxidants·Nady BraidySam van Eeden
Nov 14, 2019·International Journal of Molecular Sciences·Thomas Ho-Yin LeeSuk-Yu Yau
Oct 9, 2020·Journal of Experimental & Clinical Cancer Research : CR·Francesca ScatozzaAntonio Facchiano
Dec 18, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Mette M Berger, William Manzanares
Nov 4, 2020·International Journal of Molecular Sciences·Antonio ZandonaMaja Katalinić
Feb 12, 2021·Frontiers in Neurology·Bin LiuJingping Shi
Dec 8, 2020·Frontiers in Cellular Neuroscience·María Lacalle-AuriolesThomas M Durcan
Mar 3, 2021·Archives of Toxicology·Amin GasmiGeir Bjørklund
May 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Heba H AwadEbtehal El-Demerdash
Jun 26, 2021·Ageing Research Reviews·Mario F Munoz-PintoSandra M Cardoso
Jun 13, 2021·Journal of Critical Care·Yub Raj SedhaiMarkos G Kashiouris
Jul 16, 2021·Frontiers in Microbiology·Xiaolei WangHuanbin Xu

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BETA
deamination
transgenic

Clinical Trials Mentioned

NCT00580931
NCT03061474

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