PMID: 7540023Jan 1, 1995Paper

The influence of nitric oxide on tumour vascular tone

Acta Oncologica
G M TozerK M Bell

Abstract

Acetylcholine and sodium nitroprusside, which vasodilate via release of NO by endothelium-dependent and endothelium-independent mechanisms respectively, had little effect on tumour vascular resistance when administered to tissue-isolated tumours perfused in their normal state. However, under phenylephrine-induced vasoconstriction, sodium nitroprusside induced vasodilation whilst acetylcholine induced a small vasoconstriction. Phenylephrine itself induced an oscillatory change in tumour perfusion pressure. The nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine (L-NNA) caused a dose-dependent increase in vascular resistance in ex vivo perfused tumours which was greater than that in normal perfused hindlimbs. Systemic administration of L-NNA caused a 50% decrease in tumour blood flow which was a larger effect than in any of the normal tissues studied except spleen and skeletal muscle. Modification of NOS activity in tumours is a promising means for selective tumour blood flow modification. Investigation of endothelium-dependent versus endothelium-independent methods for modifying tumour blood flow may provide methods for further selectivity.

References

Dec 1, 1992·British Journal of Pharmacology·S P AndradeP J Piper
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Feb 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G M Tozer, C C Morris
Dec 1, 1994·British Journal of Cancer·G M TozerV J Cunningham
Aug 1, 1994·The British Journal of Radiology·D G HirstF W Flitney
Apr 30, 1993·Biochemical and Biophysical Research Communications·P J WoodJ R Vane
May 1, 1993·British Journal of Cancer·G M Tozer, K M Shaffi

❮ Previous
Next ❯

Citations

May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.