PMID: 9166968Apr 1, 1997Paper

The influence of orchidectomy on collagen glycosylation of trabecular bone in rat

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
L MoroM Romanello

Abstract

This study evaluates the effect of male rat castration on the degree of collagen glycosylation of bone. Twenty 100-day-old male Sprague-Dawley rats were subjected to either orchidectomy (n = 10) or sham operation (n = 10). After surgery animals were divided at random into 2 groups: the first group (5 sham operated and 5 orchidectomized) was sacrificed under anesthetic at 130 days of age, while the second group (5 sham operated and 5 orchidectomized) was sacrificed at 250 days of age. Femurs and tibiae were separated into cortical and trabecular bone, demineralized, hydrolyzed and analyzed by HPLC for hydroxylysine glycosides and hydroxyproline content. Orchidectomy causes an increased collagen glycosylation only in trabecular bone, as already observed in ovariectomized rats. However, the effect was not seen in the group of 130 day old rats, i.e. 30 days after orchidectomy, but was evident in the 250 day old rats, i.e. at 150 days from castration. These data suggest that collagen glycosylation could also be controlled by testosterone.

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Citations

Jan 12, 2011·The Journal of Biological Chemistry·Marnisa SricholpechMitsuo Yamauchi
Feb 23, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P A DawsonJ C Marini
May 11, 2012·The Journal of Biological Chemistry·Marnisa SricholpechMitsuo Yamauchi
Jun 20, 2012·Essays in Biochemistry·Mitsuo Yamauchi, Marnisa Sricholpech

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