The influence of ovariectomy on ob gene expression in rats

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
N YonedaT Aono

Abstract

Ovarian steroid hormones exert major influences on eating behaviour and body weight regulation of female rats. Ovariectomy (OVX) results in an increase in food intake and a concomitant increase in body weight, while estradiol (E2) replacement reverses these effects. In this study, we examined the influence of OVX on obese (ob) gene expression in rat adipose tissues and serum leptin concentration. Female Wistar rats, 10 weeks old, were divided into three groups: sham-operated control rats receiving corn oil (group 1, n = 4), ovariectomized rats receiving corn oil (group 2, n = 5), and ovariectomized rats receiving 17beta-E2 (10 microg/kg/day) replacement (group 3, n = 4). After 4 weeks, the rats and food consumption were weighed and serum E2 and leptin levels were measured by radioimmunoassays. Furthermore, the expression levels of ob mRNA obtained from the bilateral perimetric fat pads were estimated by Northern blot analysis. The mean weight and food consumption in group 2 were significantly (p < 0.01) heavier than those in group 1. But there were no significant differences between group 1 and group 3. The expression levels of ob mRNA in group 2 were lower than those in group 1, however, the levels of group 3 were restored to ...Continue Reading

Citations

Jan 5, 2002·Steroids·Darrell W BrannClint D Buchanan
Aug 15, 2000·Molecular and Cellular Endocrinology·B MorashM Wilkinson
Mar 24, 2004·Journal of Assisted Reproduction and Genetics·Corrine K WeltChristos S Mantzoros
Apr 11, 2012·International Journal of Molecular Sciences·Chen-Chen WuZhe Wang
Dec 19, 2003·Advances in Renal Replacement Therapy·Peter StenvinkelBengt Lindholm
Jan 3, 2012·Archives of Gynecology and Obstetrics·Soudabeh FallahMohsen Korani
Jan 14, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Wenjuan LiJing Zhang
Dec 5, 2008·Maturitas·Mansor FazlianaClaes-Göran Ostenson
May 30, 2008·Life Sciences·Jeong A ParkSun Yeou Kim
Mar 15, 2015·Archives of Oral Biology·Marcio SalazarOsmar Aparecido Cuoghi
Aug 21, 2009·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yumi SatoKen Haruma
May 28, 2014·Journal of Chemical Neuroanatomy·Jeanette C Valleau, Elinor L Sullivan
Jul 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hasan YükselOkay Başak
Mar 21, 2002·American Journal of Obstetrics and Gynecology·Michal NowickiFranciszek Kokot
Nov 26, 1999·Obesity Research·S Wu-PengR L Leibel
Jan 29, 2002·Biochemical and Biophysical Research Communications·Mitsuhiro KimuraToshihiro Aono
Nov 4, 2005·Biology of Reproduction·Michael C Henson, V Daniel Castracane
Jun 22, 2000·Biology of Reproduction·N Kronfeld-SchorE P Widmaier
Jan 31, 2007·Brazilian Dental Journal·Ana Lia AnbinderRosilene Fernandes da Rocha
Dec 26, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D A AinslieA W Thorburn
Oct 2, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J S Mayes, G H Watson
Jan 24, 2007·Menopause : the Journal of the North American Menopause Society·Costantino Di CarloCarmine Nappi
Jul 18, 2009·Menopause : the Journal of the North American Menopause Society·Cristina Laguna Benetti-PintoHeraldo Mendes Garmes
Mar 11, 2003·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C Di CarloC Nappi
Jan 11, 2005·Arquivos brasileiros de endocrinologia e metabologia·Leonardo S VasconcellosAndy Petroianu
May 18, 1999·The American Journal of Physiology·M A PelleymounterM McCaleb
Aug 28, 2003·Endocrine Journal·Tsutomu DouchiYukihiro Nagata
Feb 28, 2003·Diabetes·Deborah J CleggStephen C Woods
Jan 3, 2001·Journal of Applied Physiology·M G LatourJ M Lavoie

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