The Influence of Oxidative Stress and Natural Antioxidants on Morphometric Parameters of Red Blood Cells, the Hemoglobin Oxygen Binding Capacity, and the Activity of Antioxidant Enzymes

BioMed Research International
Victor V RevinTatyana P Kuzmenko

Abstract

Using a wide range of different physical and chemical methods, it was found that the oxidative stress caused by addition of hydrogen peroxide to the incubation medium has a significant effect on the conformation of haematoporphyrin, influencing the oxygen-binding properties of haemoglobin in red blood cells. Morphofunctional characteristics of red blood cells change; in particular, we have observed the transformation of erythrocytes, their transition into echinocytes. In erythrocytes, in response to increased lipid peroxidation (LPO) antioxidant enzymes become active. The use of natural antioxidants (β-carotene and resveratrol) works towards reducting the level of oxidative processes. Resveratrol has the greatest antioxidant effect.

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Citations

Jul 15, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Justin Kok Soon TanRupesh Agrawal
Jun 6, 2021·The Journal of Nutritional Biochemistry·Paula R AugustiTatiana Emanuelli
Jul 14, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Biljana Davidović-PlavšićMirjana Žabić
Dec 7, 2021·Drug and Chemical Toxicology·Francis J Olatoye, Abidemi J Akindele

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