PMID: 3757150Aug 1, 1986Paper

The influence of oxygenated sterol compounds on dipalmitoylphosphatidylcholine bilayer structure and packing

Chemistry and Physics of Lipids
M RooneyJ W Kauffman

Abstract

Fourier Transform Infra-red and Raman Spectroscopies indicate that 7 alpha-hydroxycholesterol and 7-ketocholesterol have a diminished capacity to condense (increase the packing order of) fluid-state dipalmitoylphosphatidylcholine (DPPC) acyl chains when compared with the effects of cholesterol and the other oxidized sterols studied. DPPC head groups were also more ordered by 7-ketocholesterol over the temperature range 10 degrees - 70 degrees C. Primary effects of these sterols appear to be associated with the hydrophillic regions of the DPPC bilayer, although packing arrangements with acyl chains are also involved. Phosphate and acyl chain ester groups were observed to possess a packing order which was invariant which indicates that these may be the target groups in the interaction with 7-ketocholesterol. A surprising observation was the synergistic amplification of the effects of 7-ketocholesterol by the presence of cholesterol in the DPPC bilayer.

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Citations

Sep 1, 1994·Lipids·O KüçükM P Westerman
Feb 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F GuardiolaJ Boatella
Jan 1, 1989·Free Radical Biology & Medicine·L L Smith, B H Johnson
Aug 24, 2001·Chemistry and Physics of Lipids·A M Smondyrev, M L Berkowitz
Jan 27, 1999·Atherosclerosis·A J Brown, W Jessup
Jun 30, 1998·Prostaglandins & Other Lipid Mediators·M DushkinV Kozlov
Mar 10, 2016·Chemistry and Physics of Lipids·Waldemar KuligIlpo Vattulainen
Nov 27, 1987·Biochimica Et Biophysica Acta·J H IpsenM J Zuckermann
Mar 18, 2016·The Journal of Biological Chemistry·Monika Bokori-BrownC Peter Winlove
Sep 1, 1992·European Journal of Pharmacology·R M ZwijsenL H de Haan

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