PMID: 20118630Feb 2, 2010Paper

The influence of Parachlorella beyerinckii CK-5 on the absorption and excretion of methylmercury (MeHg) in mice

The Journal of Toxicological Sciences
Takuya UchikawaYotaro Ando

Abstract

Chlorella (Parachlorella beyerinckii CK-5), previously identified as Chlorella vulgaris CK-5, is a unicellular green algae that has for many years been used as a nutritional supplement. In order to investigate the effects of methylmercury (MeHg) detoxification by Chlorella, we examined the absorption and excretion of MeHg in mice. Female C57BL/6N mice were randomly divided into three groups of five, and were housed in metabolism cages. Mice were orally administered MeHg chloride at doses of 5 mg (4 mg Hg)/kg body weight with or without 100 mg/mouse of P. beyerinckii powder (BP), and were assigned to either a MeHg group or MeHg + BP group, accordingly. Twenty-four hr after oral administration, feces and urine were collected, and blood, liver, and kidney samples were obtained. Total mercury contents in the samples obtained were determined using an atomic absorption method. The amounts of Hg excreted in feces and urine of the MeHg + BP group were increased nearly 1.9 and 2.2-fold compared with those of the MeHg group. On the other hand, blood and organ Hg levels were not significantly different between two groups. These results suggest that the intake of BP may induce the excretion of Hg both in feces and urine, although it does n...Continue Reading

References

Jan 1, 1989·Archives of Toxicology·A YasutakeM Inoue
Apr 1, 1983·The American Journal of Physiology·N Ballatori, T W Clarkson
Dec 11, 1999·Public Health Reports·K R Mahaffey
Sep 26, 2007·Archives of Environmental & Occupational Health·René CanuelIsabelle Rheault
Oct 1, 2008·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Veronica Almaguer CantuJose Angel Loredo-Medrano
Oct 15, 2009·Toxicology and Industrial Health·Takuya UchikawaYotaro Ando

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Citations

Feb 9, 2012·Journal of Environmental and Public Health·Margaret E Sears, Stephen J Genuis
Dec 20, 2014·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·A V Klein, H Kiat
Oct 20, 2011·The Journal of Toxicological Sciences·Takuya UchikawaAkira Yasutake
Feb 8, 2011·The Journal of Toxicological Sciences·Takuya UchikawaAkira Yasutake
Jun 25, 2014·Food & Function·Silvia BuonoVincenzo Fogliano
Aug 23, 2020·Nutrients·Tomohiro BitoFumio Watanabe
Apr 2, 2021·Biological & Pharmaceutical Bulletin·Masaaki NaganoYoshiyuki Seko

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