The influence of paternal diet on sncRNA-mediated epigenetic inheritance

Molecular Genetics and Genomics : MGG
Line Katrine KlastrupAnders Lade Nielsen

Abstract

The risk of developing metabolic diseases is conferred by genetic predisposition from risk genes and by environmental exposures that can manifest in epigenetic changes. The global rise in obesity and type II diabetes has motivated a search for the epigenetic factors underlying these diseases. The possibility of transgenerational inheritance of epigenetic changes raises questions regarding how spermatozoa transmit acquired epigenetic changes that affect the metabolic health of the next generation. The purpose of this review is to describe current key literature concerning small non-coding RNA (sncRNA), specifically (1) the effects of high-fat or low-protein diets on sncRNA presence in spermatozoa; (2) sncRNA transmission from father to offspring; and (3) the functional effects of inherited sncRNA on offspring metabolic phenotype. Current research has identified alterations in the content of sncRNA subtypes, including microRNA (miRNA), Piwi-interacting RNA (piRNA), and transferRNA (tRNA)-derived small non-coding RNA (tsncRNA), in spermatozoa in response to both high-fat diets and low-protein diets. The altered content of spermatozoa sncRNA due to high-fat diets was associated with a changed phenotype in offspring, with offspring ...Continue Reading

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Citations

May 5, 2020·PloS One·Ismail SariLale Karakoc Sokmensuer
Jul 11, 2020·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Brilliance Onyinyechi Anyanwu, Orish Ebere Orisakwe
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Aug 28, 2021·Nutrients·Pauline DimofskiBrigitte Leininger-Muller
Jul 14, 2019·Seminars in Cell & Developmental Biology·Carlos Guerrero-Bosagna

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Methods Mentioned

BETA
PCR
RNA-seq

Software Mentioned

Fullston

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