The influence of perceptual training on working memory in older adults.

PloS One
Anne S BerryAdam Gazzaley

Abstract

Normal aging is associated with a degradation of perceptual abilities and a decline in higher-level cognitive functions, notably working memory. To remediate age-related deficits, cognitive training programs are increasingly being developed. However, it is not yet definitively established if, and by what mechanisms, training ameliorates effects of cognitive aging. Furthermore, a major factor impeding the success of training programs is a frequent failure of training to transfer benefits to untrained abilities. Here, we offer the first evidence of direct transfer-of-benefits from perceptual discrimination training to working memory performance in older adults. Moreover, using electroencephalography to evaluate participants before and after training, we reveal neural evidence of functional plasticity in older adult brains, such that training-induced modifications in early visual processing during stimulus encoding predict working memory accuracy improvements. These findings demonstrate the strength of the perceptual discrimination training approach by offering clear psychophysical evidence of transfer-of-benefit and a neural mechanism underlying cognitive improvement.

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References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A Karni, D Sagi
Jan 1, 1987·Vision Research·K Ball, R Sekuler
Jan 1, 1973·Perception·V S Ramachandran, O Braddick
Sep 4, 1980·Nature·A Fiorentini, N Berardi
Jan 1, 1995·Annual Review of Neuroscience·R Desimone, J Duncan
Sep 15, 1994·Early Human Development·R WigfieldP J Fleming
Jan 1, 1995·Psychophysiology·G R Mangun
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·C D Gilbert
Sep 16, 1993·Nature·A Karni, D Sagi
Feb 14, 1998·Neuropsychologia·M Fahle, I Daum
Nov 24, 1999·Journal of Neurophysiology·S P AhlforsR J Ilmoniemi
Mar 4, 2000·Nature Neuroscience·M Sigman, C D Gilbert
Aug 1, 2000·Vision Research·M Bach, M B Hoffmann
Sep 26, 2000·Microscopy Research and Technique·L K Langley, D J Madden
Apr 9, 2001·Vision Research·G WestheimerC D Gilbert
Jun 2, 2001·The Journal of the Acoustical Society of America·C AlainB Schneider
Jul 10, 2003·Experimental Brain Research·J Peter Maurer, Michael Bach
Nov 5, 2003·BMC Geriatrics·Tzvi DwolatzkyHoward Chertkow
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tianming Yang, John H R Maunsell
Aug 28, 2004·Journal of Vision·Sven P HeinrichMichael B Hoffmann
Apr 16, 2005·Current Opinion in Neurobiology·Manfred Fahle
Aug 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Henry W MahnckeMichael M Merzenich
Oct 19, 2006·Progress in Brain Research·Henry W MahnckeMichael M Merzenich
Oct 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ikuko MukaiLeslie G Ungerleider
Dec 18, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claude Alain, Joel S Snyder
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Adam GazzaleyMark D'Esposito
Feb 10, 2009·The European Journal of Neuroscience·Manuel MercierOlaf Blanke
May 6, 2009·Journal of Cognitive Neuroscience·Aaron M RutmanAdam Gazzaley
Aug 4, 2009·Cerebral Cortex·Wesley C ClappAdam Gazzaley
Aug 12, 2009·Neuropsychologia·Theodore P ZantoAdam Gazzaley
Sep 24, 2009·Cyberpsychology & Behavior : the Impact of the Internet, Multimedia and Virtual Reality on Behavior and Society·Lennart E NackeCraig A Lindley

❮ Previous
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Citations

Aug 6, 2014·Nature Communications·Sarah Shizuko MorimotoGeorge S Alexopoulos
Jun 21, 2012·Nature Reviews. Neuroscience·Cheryl Grady
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Samira AndersonNina Kraus
Jun 1, 2012·Games for Health Journal·Jyoti MishraAdam Gazzaley
Dec 13, 2012·Psychonomic Bulletin & Review·Anastasia Kiyonaga, Tobias Egner
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sophia VinogradovEtienne de Villers-Sidani
Jul 20, 2012·Attention, Perception & Psychophysics·L Gregory AppelbaumStephen R Mitroff
Dec 26, 2015·Experimental Gerontology·Mónica MuiñosSoledad Ballesteros
Apr 3, 2012·Brain and Cognition·Sheida Rabipour, Amir Raz
Jan 8, 2016·Journal of Cognitive Neuroscience·Todd W ThompsonJohn D E Gabrieli
Jan 26, 2016·Neural Regeneration Research·Francesco AngelucciAlberto Costa
Dec 4, 2014·Neuron·Jyoti MishraAdam Gazzaley
Aug 4, 2015·Brain Research·Jennifer L O'BrienJerri D Edwards
Dec 3, 2014·Brain Research·Cindy Lustig, Tiffany Jantz
Feb 27, 2016·Annals of the New York Academy of Sciences·Bruce S McEwen
Apr 14, 2016·Experimental Aging Research·James R HoustonDavid J Madden
Jul 31, 2013·NeuroImage·Theodore P ZantoAdam Gazzaley
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Fiona McNabRaymond J Dolan
Dec 28, 2010·Neuropsychologia·Adam Gazzaley
Jun 10, 2015·Neuroscience and Biobehavioral Reviews·Soledad BallesterosChariklia Tziraki
Nov 12, 2013·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Jerri D EdwardsJennifer J Lister
Jun 19, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jennifer L O'BrienJennifer J Lister
Sep 15, 2014·Brain Research·Jyoti MishraAdam Gazzaley
Feb 23, 2013·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Yoshio Kaneko, Matcheri Keshavan
May 2, 2014·Frontiers in Human Neuroscience·Jyoti Mishra, Adam Gazzaley
Jul 16, 2014·Frontiers in Human Neuroscience·Michael M MerzenichMor Nahum
Jul 15, 2016·Disability and Rehabilitation·Bhanu SharmaRobin E A Green
Sep 8, 2010·Behavioural Brain Research·Corinna Haenschel, David Linden
Aug 11, 2016·Frontiers in Psychology·Joyce Shaffer
Oct 14, 2011·The New England Journal of Medicine·Mark D'Esposito, Adam Gazzaley
Dec 13, 2016·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Uros MarusicVoyko Kavcic
Feb 1, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Veronica B PerezGregory A Light
Nov 11, 2015·Scientific Reports·Weifeng LiHanjun Liu
Apr 1, 2017·Translational Neurodegeneration·Bin-Yin LiSheng-Di Chen
Jun 3, 2017·The Gerontologist·Marian TzuangGeorge W Rebok
Jun 28, 2017·Journal of Cognitive Neuroscience·Camarin E RolleAdam Gazzaley

❮ Previous
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