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The influence of pH on the interaction of inhibitors with triosephosphate isomerase and determination of the pKa of the active-site carboxyl group

Biochemistry

Dec 2, 1975

Fred C. HartmanRichard V Wolfenden

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Abstract

Ionization effects on the binding of the potential transition state analogues 2-phosphoglycolate and 2-phosphoglycolohydroxamate appear to be attributable to the changing state of ionization of the ligands themselves, therefore it is unnecessary to postulate the additional involvement o...read more

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Inorganic phosphate
Phosphate ion
Inactivation
Ligands
5,5'-Dithiobis(nitrobenzoate)
Carboxyl Group
Metazoa
Chinchilla Rabbits
Hydrogen-Ion Concentration
Phosphoglycolate
168
1
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  • The influence of pH on the interaction of inhibitors with triosephosphate isomerase and determination of the pKa of the active-site carboxyl group

    Biochemistry

    Dec 2, 1975

    Fred C. HartmanRichard V Wolfenden

    PMID: 47

    DOI: 10.1021/bi00695a007

    Abstract

    Ionization effects on the binding of the potential transition state analogues 2-phosphoglycolate and 2-phosphoglycolohydroxamate appear to be attributable to the changing state of ionization of the ligands themselves, therefore it is unnecessary to postulate the additional involvement o...read more

    Mentioned in this Paper

    Inorganic phosphate
    Phosphate ion
    Inactivation
    Ligands
    5,5'-Dithiobis(nitrobenzoate)
    168
    1

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