The influence of plasma membrane electrostatic properties on the stability of cell ionic composition

Biophysical Journal
S GenetJ Burger

Abstract

An electro-osmotic model is developed to examine the influence of plasma membrane superficial charges on the regulation of cell ionic composition. Assuming membrane osmotic equilibrium, the ion distribution predicted by Gouy-Chapman-Grahame (GCG) theory is introduced into ion transport equations, which include a kinetic model of the Na/K-ATPase based on the stimulation of this ion pump by internal Na(+) ions. The algebro-differential equation system describing dynamics of the cell model has a unique resting state, stable with respect to finite-sized perturbations of various types. Negative charges on the membrane are found to greatly enhance relaxation toward steady state following these perturbations. We show that this heightened stability stems from electrostatic interactions at the inner membrane side that shift resting state coordinates along the sigmoidal activation curve of the sodium pump, thereby increasing the pump sensitivity to internal Na(+) fluctuations. The accuracy of electrostatic potential description with GCG theory is proved using an alternate formalism, based on irreversible thermodynamics, which shows that pressure contribution to ion potential energy is negligible in electrostatic double layers formed at t...Continue Reading

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Citations

Feb 11, 2010·Journal of Diabetes Science and Technology·Ilana Harman-BoehmYulia Mayzel
Apr 17, 2018·Plant & Cell Physiology·Christoph-Martin Geilfus
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ben HarlandSean X Sun
Jul 21, 2010·Nanoscale·Sonia Antoranz ConteraJohn F Ryan
May 20, 2018·Physical Review. E·Jingyuan ChenZhenwei Yao
Jun 2, 2010·Journal of Diabetes Science and Technology·Ilana Harman-BoehmYulia Mayzel
Feb 5, 2021·European Biophysics Journal : EBJ·E Sabri, C Brosseau
Jan 3, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Shayandev SinhaSiddhartha Das
Jul 21, 2006·The Journal of Physical Chemistry. B·Jian LiuArup K Chakraborty

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