The influence of plasma triglycerides on human growth hormone response to arginine and insulin: a study in hyperlipemics and normal subjects.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
M MuggeoG Crepaldi

Abstract

Human growth hormone (HGH) response to arginine (25 gm IV in 30 min) and to insulin (0.1 U/kg B.W.) was studied in 12 male patients (mean age 36 +/- 2 years), with normal glucose tolerance and normal body weight, affected with Fredrickson's Type IV primary hyperlipemia. The patients were examined both when plasma triglycerides (TG) were elevated and following clofibrate (2 gm/die for 30-60 days) induced TG reduction. No variations in glucose or FFA behaviour or in body weight were observed after clofibrate. HGH response to arginine was absent, while that to insulin was only inhibited, when plasma TG were elevated. A significant increase in HGH peaks after arginine (from 1.99 +/- 0.59 to 9.34 +/- 1.58 ng/ml) and a slight increment in HGH peaks after insulin (from 23.09 +/- 7.19 to 31.46 +/- 7.95 ng/ml) were observed following reduction in plasma TG. Arginine test was carried out in 7 normal subjects during saline infusion and at the 3rd hour of lipid infusion (Intralipid 20%). HGH response to arginine was absent in all of the subjects during lipid infusion. The HGH response to insulin test, carried out in 9 other normal subjects during saline infusion and at the 3rd hour of lipid infusion (Lipiphysan 15%) was significantly inhib...Continue Reading

Citations

Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·T MorojiI Matsuzaki
Mar 1, 1989·Journal of Affective Disorders·R ThomasM Scanlon
Sep 27, 2015·Molecular and Cellular Endocrinology·Richard C Lindsey, Subburaman Mohan
Dec 1, 1976·General and Comparative Endocrinology·C G ScanesW S Newcomer
Feb 13, 2001·Endocrine Reviews·D Le RoithA Butler
Jan 1, 1988·Clinical Endocrinology·C DieguezM F Scanlon

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