The influence of polypharmacy on grade III/IV toxicity, prior discontinuation of chemotherapy and overall survival in ovarian cancer

Gynecologic Oncology
H WoopenJ Sehouli

Abstract

Ovarian cancer is mostly diagnosed in the elderly woman who is likely to have comorbid disease and to take several comedications on a regular basis. Aim of this study was to evaluate the influence of polypharmacy on grade III/IV toxicity, prior discontinuation of chemotherapy and survival. In this individual participant data meta-analysis the original data of three phase II/III studies of the North-Eastern German Society of Gynecological Oncology (NOGGO) were analyzed using multivariate logistic and Cox regression. Overall, 1213 patients with recurrent ovarian cancer were included in these analyses. An increasing amount of medication was associated with overall grade III/IV toxicity (p<0.001; OR 1.120), and hematological (p<0.001; OR 1.056) and non-hematological (p<0.001; OR 1.134) toxicities. Prior discontinuation of chemotherapy was not influenced by an increasing amount of medication (p=0.196). There was no association of polypharmacy with overall survival (p=0.068). As polypharmacy does not influence survival ovarian cancer patients taking several comedications may be included in clinical trials and should not be deprived of adequate cancer treatment. However, a thorough monitoring is mandatory due to the increased risk of ...Continue Reading

References

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Citations

Aug 9, 2016·Journal of Geriatric Oncology·Manvi SharmaHolly M Holmes
Jul 27, 2017·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Amanda Canato FerraciniPriscila Gava Mazzola
Apr 7, 2019·The Oncologist·Sean OldakMatthew Schlumbrecht
Oct 21, 2018·The Oncologist·Ryan D NippJennifer S Temel
Mar 12, 2020·Leukemia & Lymphoma·Prajwal DhakalVijaya Raj Bhatt
Oct 18, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Monira AlwhaibiBander Balkhi
May 28, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Li-Ju ChenBen Schöttker
Mar 7, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Irena RohrJalid Sehouli
Jul 22, 2017·The Cancer Journal·Ginah NightingaleManpreet K Boparai
Apr 22, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Deniz C GuvenSuayib Yalcin
Dec 24, 2020·Journal of Geriatric Oncology·Ashley BarlowGinah Nightingale

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