The influence of pre-eclampsia on fetal lung maturity

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Tea ŠtimacAleks Finderle

Abstract

To use amniotic fluid (AF) lamellar body count (LBC) to assess the influence of pre-eclampsia and associated pathologic conditions on fetal lung maturity (FLM). A prospective study was conducted to analyze 378 AF samples containing 5 mL of AF from 306 singleton pregnancies at 26-39 weeks. Stratified by gestational age groups, pregnancies were categorized as follows: pre-eclampsia (n=25); intrauterine growth restriction (IUGR) (n=74); pre-eclampsia and IUGR (n=63); and control (n=144). Amniotic fluid LBC in each group was estimated and medians were compared for defined gestational age periods. Statistical analyses were performed via non-parametric tests. Between 31 and 33 weeks, significantly lower median LBCs were found in the pre-eclampsia group than in the IUGR group (P=0.022) and in pregnancies with both entities (P=0.031). Between 34 and 36 weeks, there were significantly lower median LBCs in the pre-eclampsia and the pre-eclampsia/IUGR groups than in the IUGR group (P=0.026 and P=0.004, respectively), as well as in the pre-eclampsia/IUGR group compared with the control group (P=0.04). Significantly lower LBCs in pre-eclamptic pregnancies between 31 and 36 weeks of gestation indicate delayed FLM associated with pre-eclampsia.

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Citations

May 21, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Ludwig GortnerErol Tutdibi
Oct 20, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiroyuki TsudaFumitaka Kikkawa
Jul 25, 2017·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Satoshi ShinoharaRei Sunami
Jun 8, 2017·American Journal of Respiratory Cell and Molecular Biology·Santhosh T SomashekarKaren C Young

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