The influence of pregnancy on the pharmacokinetic properties of artemisinin combination therapy (ACT): a systematic review

Malaria Journal
Renée J BurgerMichèle van Vugt

Abstract

Pregnancy has been reported to alter the pharmacokinetic properties of anti-malarial drugs, including the different components of artemisinin-based combination therapy (ACT). However, small sample sizes make it difficult to draw strong conclusions based on individual pharmacokinetic studies. The aim of this review is to summarize the evidence of the influence of pregnancy on the pharmacokinetic properties of different artemisinin-based combinations. A PROSPERO-registered systematic review to identify clinical trials that investigated the influence of pregnancy on the pharmacokinetic properties of different forms of ACT was conducted, following PRISMA guidelines. Without language restrictions, Medline/PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, LILACS, Biosis Previews and the African Index Medicus were searched for studies published up to November 2015. The following components of ACT that are currently recommend by the World Health Organization as first-line treatment of malaria in pregnancy were reviewed: artemisinin, artesunate, dihydroartemisinin, lumefantrine, amodiaquine, mefloquine, sulfadoxine, pyrimethamine, piperaquine, atovaquone and proguanil. The literature search identified 121 r...Continue Reading

References

Sep 1, 1979·Clinical Pharmacology and Therapeutics·R E DesjardinsC J Canfield
Oct 1, 1990·British Journal of Clinical Pharmacology·N A HelsbyA M Breckenridge
Jul 1, 1990·British Journal of Clinical Pharmacology·F NostenT Harinasuta
Jan 1, 1989·European Journal of Drug Metabolism and Pharmacokinetics·F D Juma, J O Ogeto
Aug 1, 1989·British Journal of Clinical Pharmacology·G FranssenF Bricaire
Jan 1, 1988·European Journal of Clinical Pharmacology·J KarbwangA M Breckenridge
Dec 1, 1987·British Journal of Clinical Pharmacology·Y WattanagoonN J White
Nov 1, 1985·British Journal of Clinical Pharmacology·J H RivièreR E Howells
Jan 1, 1983·Chemotherapy·I MimicaD E Schwartz
May 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·K Na BangchangJ Karbwang
Jan 1, 1993·European Journal of Clinical Pharmacology·J WangboonskulR B Taylor
May 5, 1998·Fundamental & Clinical Pharmacology·J KarbwangP Molunto
Oct 9, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·A SabchareonD B Hutchinson
Sep 24, 1999·European Journal of Clinical Pharmacology·M van VugtF Nosten
Mar 18, 2000·Antimicrobial Agents and Chemotherapy·P NewtonN White
Jul 27, 2000·Obstetrics and Gynecology·B B Little
Feb 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·R McGreadyF Nosten
Sep 5, 2003·European Journal of Clinical Pharmacology·R McGreadyF Nosten
Sep 5, 2003·European Journal of Clinical Pharmacology·R McGreadyF Nosten
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A SowunmiA O Arowojolu
Oct 21, 2006·European Journal of Clinical Pharmacology·Rose McGreadyFrançois Nosten
Jan 26, 2007·The Lancet Infectious Diseases·Meghna DesaiRobert D Newman
Oct 9, 2007·The Journal of Infectious Diseases·Michael D GreenHenry Nettey
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeanne Rini PoespoprodjoRic N Price
Jul 22, 2009·Antimicrobial Agents and Chemotherapy·Harin A KarunajeewaTimothy M E Davis
Feb 4, 2010·PLoS Medicine·Stephanie DellicourFeiko O ter Kuile
Mar 6, 2010·Advances in Experimental Medicine and Biology·Stephen J Rogerson
Mar 8, 2011·Trends in Parasitology·Alexandra J UmbersStephen J Rogerson

❮ Previous
Next ❯

Citations

Aug 11, 2016·Reproductive Toxicology·Caroline GomesPaulo Roberto Dalsenter
Oct 6, 2018·Expert Opinion on Pharmacotherapy·Brioni R Moore, Timothy M E Davis
Feb 2, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rui-Jie MaGang Zhou
Apr 3, 2019·PloS One·Maria Carmina PauFrancesco Michelangelo Turrini
Jul 31, 2020·Expert Opinion on Drug Metabolism & Toxicology·Brioni R Moore, Timothy M Davis
Jul 4, 2020·The American Journal of Tropical Medicine and Hygiene·Timothy P FinnThomas P Eisele
Oct 24, 2018·Expert Opinion on Drug Safety·Makoto SaitoFrançois Nosten
Apr 11, 2017·Journal of Travel Medicine·Camille RousselStéphane Jauréguiberry
Feb 29, 2020·Journal of Clinical Pharmacology·Juntra Karbwang, Kesara Na-Bangchang
Dec 31, 2019·Seminars in Cancer Biology·Ji Hoon JungSung-Hoon Kim
Feb 6, 2018·The Lancet Infectious Diseases·Umberto D'AlessandroEsperanca Sevene

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.