Abstract
beta-Endorphin (beta-EP) and methionine-enkephalin (M-EK) are endogenous peptides that play a role in the modification of pain perception and analgesia threshold. In order to understand more about pathophysiology of pain in association with neuroaxial blocks, we evaluated cerebrospinal fluid (CSF) concentrations of beta-EP and M-EK prior to spinal anesthesia (SA) in patients undergoing transurethral resection of prostate (TURP) to determine the correlation between preanesthesia concentrations and the duration of postoperative analgesia and opioid requirements. Twenty-five healthy patients undergoing TURP under SA were enrolled. beta-EP and M-EK were measured with a competitive radioimmunoassay. Mean preoperative beta-EP and M-EK concentrations were 153 +/- 44 and 38 +/- 5 pg/mL, respectively. Those with beta-EP concentrations > 153 pg/mL had significantly longer analgesia (P < 0.01), and lower utilization of morphine in the first postoperative day (P < 0.01). Moreover, patients with milder postoperative pain (visual analog scale score < 4/10) had significantly higher beta-EP concentrations (P < 0.01). A similar correlation was not found with M-EK values. These data suggest that preoperative CSF beta-EP, but not M-EK, concentrat...Continue Reading
References
Jun 14, 1991·Brain Research·S BourgoinF Cesselin
Oct 1, 1988·Biological Psychiatry·C P O'BrienI Eriksson
Sep 30, 1985·Life Sciences·W H BerrettiniE S Gershon
Apr 1, 1986·Archives of General Psychiatry·M A RaskindD Dorsa
Aug 31, 1987·Life Sciences·T R KostenL Ferdinands
Jul 1, 1985·Neurology·R SulkavaT Laatikainen
Jan 19, 1980·Lancet·T OyamaR Guillemin
Apr 5, 1980·Lancet·A TamsenL Terenius
Nov 1, 1980·Lancet·V Clement-JonesH L Wen
May 11, 1981·Life Sciences·P L WoodJ Richard
Jul 1, 1982·Physiological Reviews·D De Wied, J Jolles
Jun 1, 1982·Pain·A TamsenP Hartvig
Dec 21, 1981·Brain Research·A W DugganC R Morton
Sep 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A R GenazzaniF Savoldi
Mar 1, 1984·Neurology·C S CleelandW Orrison
Feb 1, 1984·Pain·A R GenazzaniF Savoldi
Aug 1, 1983·Life Sciences·T HazatoK Kaya
Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·L Terenius, A Tamsen
Citations
Aug 21, 2008·Aesthetic Plastic Surgery·Alan A ParsaF Don Parsa
May 27, 1997·Transplantation·K L DonovanC W Pinson
Jan 23, 2003·Anesthesia and Analgesia·Reginald MatejecHansjörg Teschemacher
Dec 14, 2012·PloS One·Shu-Lin GuoChien-Sheng Chen
Feb 18, 2012·European Journal of Pain : EJP·S BruehlM Chont
Nov 18, 2005·Neuropeptides·Reginald MatejecHansjörg Teschemacher
Jul 20, 2002·The Journal of Surgical Research·Po Chang LeeKuei Sen Hsu