PMID: 590312Dec 2, 1977

The influence of prolonged treatment with D-penicillamine on the immune response in Wilson's disease

European Journal of Clinical Pharmacology
A Czlonkowska

Abstract

Humoral and cell-mediated immunity were studied in a group of patients with Wilson's disease not previously treated with D-penicillamine, and in a group of patients treated with the drug for more than two years. The previously untreated patients showed an exaggerated humoral immune response, i. e. increased levels of IgG and, IgM, higher titer of antibodies to Kunin's antigen, and depression of cell-mediated immunity, namely a decreased response to DNCB, decreased lymphocyte transformation after stimulation with Con A, PPD, Candida and streptokinase and a reduced response to streptokinase in the MIF test. After treatment the humoral response returned to normal, and in the case of IgA and antibodies to S. typhi O antigen, it even dropped below normal values. The cell-mediated immune response returned to normal with the exception of lymphocyte transformation by PHA and Candida albicans. In in vitro studies it was found that D-penicillamine had no influence on lymphocyte transformation when PHA and Con A were used as mitogens. With PPD as antigen, lymphocyte stimulation and migration inhibition were inhibited by concentrations of penicillamine ranging from 6 to 1000 microgram/ml.

References

Oct 1, 1976·Journal of the Neurological Sciences·A Czlonkowska, B Milewski
Aug 15, 1974·Klinische Wochenschrift·U JungeE Lubrich
Mar 22, 1973·The New England Journal of Medicine·I A Jaffe
May 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·R BaumgartnerH C Stoerk
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Apr 1, 1971·The Quarterly Journal of Medicine·K Gibbs, J M Walshe
Oct 1, 1956·The American Journal of Medicine·J M Walshe
Jul 1, 1961·Journal of Clinical Pathology·S HANNA

Citations

Mar 3, 2005·Journal of Neurology·Anna CzłonkowskaM Rodo
Oct 1, 1976·Journal of the Neurological Sciences·A Czlonkowska, B Milewski
Nov 1, 1979·Journal of the Neurological Sciences·Anna CzłonkowskaJ Korlak
Nov 1, 1981·Canadian Anaesthetists' Society Journal·A J CunninghamA G Watson
Jul 1, 1985·Canadian Anaesthetists' Society Journal·J Lerman, A A Kiskis

Related Concepts

Cell Migration Inhibition Measurement
Hepatic Form of Wilson Disease
IgA2
Polyglobin
IgM2
Cellular Immune Response
Leukocytes
Lymphocyte Activation
Metalcaptase
Hypersensitivity Skin Testing

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