The influence of propofol anesthesia exposure on nonaversive memory retrieval and expression of molecules involved in memory process in the dorsal hippocampus in peripubertal rats

Paediatric Anaesthesia
Željko PavkovićVesna Pešić

Abstract

The effects of anesthetic drugs on postoperative cognitive function in children are not well defined and have not been experimentally addressed. The present study aimed to examine the influence of propofol anesthesia exposure on nonaversive hippocampus-dependent learning and biochemical changes involved in memory process in the dorsal hippocampus, in peripubertal rats as the rodent model of periadolescence. The intersession spatial habituation and the novel object recognition tasks were used to assess spatial and nonspatial, nonaversive hippocampus-dependent learning. The exposure to anesthesia was performed after comparably long acquisition phases in both tasks. Behavioral testing lasted for 2 consecutive days (24-hour retention period). Changes in the expression of molecules involved in memory retrieval/reconsolidation were examined in the dorsal hippocampus by Western blot and immunohistochemistry, at the time of behavioral testing. Exposure to propofol anesthesia resulted in inappropriate assessment of spatial novelty at the beginning of the test session and affected continuation of acquisition in the spatial habituation test. The treatment did not affect recognition of the novel object at the beginning of the test session ...Continue Reading

References

Oct 9, 2002·Neuron·Liliana MinichielloMartin Korte
Jan 7, 2003·Neurochemical Research·German SzapiroJorge H Medina
Sep 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nicola J BroadbentRobert E Clark
May 18, 2006·Reviews in the Neurosciences·Colin LeverJohn O'Keefe
Jun 16, 2006·Neuroscience and Biobehavioral Reviews·Melanie P Leussis, Valerie J Bolivar
Feb 8, 2007·Reviews in the Neurosciences·Maria Grazia Giovannini
Apr 13, 2011·Trends in Cognitive Sciences·John T Wixted, Larry R Squire
Feb 6, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ellen C Jensen
Aug 30, 2014·Behavioural Brain Research·Sarah J Cohen, Robert W Stackman
Oct 16, 2014·Behavioural Brain Research·E C Warburton, M W Brown
Oct 9, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew L EagleAlfred J Robison
Oct 27, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Vesna PešićSabera Ruždijić
Oct 25, 2016·ELife·Maria DiamantakiAndrea Burgalossi
Jun 24, 2017·Scientific Reports·Fabio Antonio VigilKarl Peter Giese

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Citations

Feb 19, 2020·Alcoholism, Clinical and Experimental Research·Justine D LandinDavid F Werner
Apr 3, 2020·PloS One·Juliane RudeckLars Lewejohann
Sep 13, 2020·Journal of Neuroinflammation·Flora ReverchonArnaud Menuet
Nov 26, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Milica PotrebićVesna Pešić

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