The influence of prostacyclin on coronary occlusion induced arrhythmia in cats

Prostaglandins and Medicine
R K DixT Lawrence

Abstract

The present study examined the effect of prostacyclin (PGI2) on ventricular arrhythmias following coronary artery occlusion in the cat. The left anterior descending coronary artery (LAD) was occluded abruptly in 50 cats anesthetized with alpha-chloralose. The ECG (Lead II) along with arterial blood pressure were monitored before and for at least one hour after occlusion. Either vehicle or PGI2 was infused at a rate of 0.15 ml . min-1 into the left atrium 15 min before and 1 hour after LAD occlusion. PGI2 was infused at 4 doses: 2.7,27,270 and 2700 pmole . kg-1 . min-1. Infusion of PGI2 before occlusion produced a dose dependent decrease in mean arterial blood pressure with no significant change in heart rate. Abrupt occlusion of the LAD produced ventricular arrhythmia in all cats ranging from ventricular premature beats to ventricular fibrillation (VF). In cats infused with PGI2 the incidence of VF ranged from 30-40% at the low and middle doses to a maximum of 60% at the highest dose (2700 pmole . kg-1 . min-10. The incidence of VF in the latter group was two times greater than that observed in the control group (30%). In addition, the mean number of ventricular ectopic beats was greater at the 27 and 2700 pmole . kg-1 . min-1 ...Continue Reading

References

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Citations

Apr 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dairong WangGarret A FitzGerald
Nov 1, 1981·Prostaglandins and Medicine·H J Mest, W Förster
Jan 1, 1983·Annals of the New York Academy of Sciences·J C de la Torre
Jun 1, 1988·Clinical Physiology·K Herbaczynska-CedroA Wennmalm

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