The influence of prostaglandins on the contractile response to electrical field stimulation in rabbit myometrial and cervical smooth muscles

European Journal of Pharmacology
T OkawaH Nakanishi

Abstract

Indomethacin (10 microM) significantly reduced the contractile responses to electrical field stimulation (EFS) in the non-pregnant myometrium (5-50 Hz by an average of 25.7%) and the pregnant myometrium (30-50 Hz by an average of 16.5%). On the other hand, it significantly increased the contractile responses of the cervix in non-pregnant (2.5-30 Hz by an average of 21.5%) and pregnant (2.5-10 Hz by an average of 12.5%) muscular strips. Prostaglandin (PG) E2 (0.1-1000 nM) strongly and PGI2 (0.1-1000 nM) slightly and dose-dependently inhibited the contractile response to EFS of the non-pregnant cervical muscle, but not of the myometrium. In the pregnant uterus, the contractile responses of the cervical muscle were similar to those of the non-pregnant cervix, while the response of the myometrium was increased significantly and dose-dependently by the application of PGE2 or PGI2.PGF2 alpha (1000 nM) significantly increased the contractile response of the myometrium but not cervical muscle to EFS in the pregnant rabbits. In non-pregnant muscles, the contractile responses of the myometrium and cervical smooth muscle to EFS were not influenced by the treatment with PGF2 alpha.PGE2 (0.1-1000 nM) also inhibited the contractile response ...Continue Reading

References

May 1, 1979·Prostaglandins·K I WilliamsE Marcinkiewicz
Nov 1, 1979·Prostaglandins·M H Abel, R W Kelly
Feb 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·T EndoH D Taube
Sep 1, 1975·British Journal of Pharmacology·W Feniuk, B J Large
May 1, 1970·Acta Physiologica Scandinavica·P HedqvistA Wennmalm
Aug 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·H Nakanishi, C Wood
Dec 1, 1974·British Journal of Pharmacology·M Hollingsworth
Oct 1, 1984·British Journal of Obstetrics and Gynaecology·A R Fuchs, F Fuchs
Aug 1, 1981·The Journal of Pharmacy and Pharmacology·O YagasakiI Yanagiya
Oct 1, 1983·British Journal of Pharmacology·R M Gaion, M Trento
Jan 1, 1984·Gynecologic and Obstetric Investigation·M WiklandN Wiqvist
Jan 1, 1967·British Journal of Pharmacology and Chemotherapy·S M KarimE D Williams

❮ Previous
Next ❯

Citations

Dec 1, 1993·Asia-Oceania Journal of Obstetrics and Gynaecology·T OkawaH Nakanishi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.