The influence of protein binding on the antibacterial activity of faropenem against Haemophilus influenzae

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
I Gustafsson, O Cars

Abstract

The effects of albumin and human serum on the pharmacodynamics of faropenem were studied. The protein binding of faropenem was 91-95%, corresponding to the increase in MICs for Haemophilus influenzae in broth supplemented with albumin. Time-kill experiments in albumin-containing medium and in inactivated human serum 50% v/v showed that much higher drug concentrations were needed to achieve a bactericidal effect than were needed in broth. Active human serum alone exerted a strain-dependent bactericidal effect. It was concluded that it is the free fraction of faropenem in serum that has antibacterial activity against H. influenzae.

References

Jan 1, 1997·Journal of Pharmaceutical Sciences·A KovarH Derendorf
Jan 1, 1997·The Journal of Antimicrobial Chemotherapy·J M WoodcockR Wise
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
Apr 30, 2002·International Journal of Antimicrobial Agents·Ping LiuHartmut Derendorf
Oct 3, 2002·The Journal of Antimicrobial Chemotherapy·F J BoswellR Wise

Citations

May 4, 2011·Antimicrobial Agents and Chemotherapy·Markus ZeitlingerUrsula Theuretzbacher
Dec 21, 2007·The Annals of Pharmacotherapy·Jacob P GettigAlexander H Philbrick
Nov 22, 2017·Antimicrobial Agents and Chemotherapy·A Dalhoff
Apr 5, 2013·Clinical Microbiology Reviews·Daniel GonzalezHartmut Derendorf

Related Concepts

(5R,6S)-6-(R)-1-hydroxyethyl-7-oxo-3-(R)-2-tetrahydrofuryl-4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylate
Beta-Lactamase
Haemophilus Infections
Haemophilus influenzae
Lactims
Fungus Drug Sensitivity Tests
Plasma Protein Binding Capacity
Plasma Albumin
Streak Plate Count
Serum Bactericidal Test

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.