The influence of reducing fever on blood oxygen saturation in children

European Journal of Pediatrics
Shmuel GoldbergElie Picard

Abstract

Laboratory-based studies on the oxyhemoglobin dissociation curve (ODC) suggest that high blood temperature decreases the affinity of hemoglobin for oxygen. The aim of the study was to evaluate the influence of pyrexia on oxygen saturation (SpO2) in children presenting to the emergency department. Normoxemic children with body temperature at or above 38.5 °C were included. Patients with a dynamic respiratory disease were excluded. SpO2 was measured before and after antipyretic treatment. The changes in body temperature and SpO2 were assessed and compared to the changes predicted from the ODC. Thirty-four children completed the study. Mean temperature at presentation was 39.17 ± 0.549 °C and mean SpO2 was 96.15 ± 2.21%. The mean decrease in temperature after antipyretic treatment was 1.71 ± 0.67 °C and mean increase in SpO2 was 0.95 ± 1.76%. Among children in whom pyrexia decreased by 1.5 °C or more, the mean increase in SpO2 was 1.45 ± 1.57%. The measured increase in SpO2 was close to the increase anticipated from the ODC. Pyrexia was associated with decreased SpO2 in normoxemic children. The influence of pyrexia in children with low-normal oxygen saturation is expected to be much higher because of the non-linear shape of the OD...Continue Reading

References

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Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·R A Wood, P A Eggleston
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Jun 16, 2009·Internal and Emergency Medicine·Camilla TozzettiPietro Amedeo Modesti

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Citations

Aug 10, 2019·European Journal of Pediatrics·Jan TellerSebastiano A G Lava

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