The influence of rejection episodes in recipients of bilateral corneal grafts.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Keryn A Williamsall contributors to the Australian Corneal Graft Registry

Abstract

We investigated whether a rejection episode in one graft was associated with rejection in the other graft, in recipients with bilateral corneal transplants. In a prospectively maintained, national register of 14,865 followed corneal grafts, 1476 patients with bilateral penetrating corneal grafts were identified. Occurrence of rejection was a risk factor for graft failure (p < 0.0001). Logistic regression was used to calculate the adjusted odds ratio for rejection in one eye following rejection in the other eye. In the subset of 1118 patients with bilateral grafts but no history of previous grafts or rejections in either eye, the adjusted odds ratio for a rejection episode in the first eye following rejection in the second was 3.27 (95% confidence interval, CI 1.85, 5.79; p < 0.001). The adjusted odds ratio was 2.04 (95% CI 1.07, 3.91; p = 0.03) for rejection in the second eye following rejection in the first. The median time between the first rejection episode in one eye and the first rejection episode in the other eye was 15 months. Patients with bilateral corneal grafts who suffer a graft rejection episode in one eye are at significantly greater odds of suffering a rejection episode in the other corneal transplant.

References

Aug 1, 1989·Ophthalmology·D C Musch, R F Meyer
Aug 15, 1994·American Journal of Ophthalmology·W M BourneL R Nelson
Oct 27, 1998·Ophthalmology·J J IngW M Bourne
Sep 6, 2000·Transplantation·H J Völker-DiebenJ D'Amaro
Nov 30, 2000·Clinical & Experimental Ophthalmology·N H BarkerK A Williams
Jul 27, 2001·Cornea·W M Bourne
Nov 12, 2002·International Reviews of Immunology·Joan Stein-Streilein, J Wayne Streilein
Jan 9, 2003·Expert Opinion on Investigational Drugs·Sanjiv Banerjee, Andrew D Dick
Jul 29, 2003·Investigative Ophthalmology & Visual Science·W John ArmitageWilliam M Bourne
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J T George, D F P Larkin
Apr 16, 2004·Transplantation·Sanjiv BanerjeeSusan M Nicholls
Nov 27, 2004·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Eckart Bertelmann, Uwe Pleyer
Dec 27, 2005·American Journal of Ophthalmology·Douglas J Coster, Keryn A Williams
Mar 22, 2006·Nature Immunology·Jerry Y Niederkorn
Nov 7, 2007·Transplantation·Keryn A Williams, Douglas J Coster
Dec 24, 2008·Transplantation·Keryn A WilliamsUNKNOWN All Contributors
Aug 20, 2009·JAMA : the Journal of the American Medical Association·Nancy A Dreyer, Sarah Garner

❮ Previous
Next ❯

Citations

Feb 5, 2016·Survey of Ophthalmology·Antony ClarkJames B Semmens
Apr 16, 2011·Journal français d'ophtalmologie·E GuilbertV Borderie
Jan 29, 2013·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Sven JonuscheitKanna Ramaesh
Apr 16, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K J PaunickaJ Y Niederkorn
Apr 15, 2011·American Journal of Ophthalmology·Vincent M BorderieLaurent Laroche
Nov 14, 2013·Clinical & Developmental Immunology·Qiquan Sun, Yang Yang
Aug 6, 2016·American Journal of Ophthalmology·Bernhard StegerUNKNOWN National Health Service Blood and Transplant Ocular Tissue Advisory Group and Contributing Ophthalmologists (OTAG Audit Stud
Jul 24, 2014·The Cochrane Database of Systematic Reviews·Miriam KeaneKeryn Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.