The influence of saliva flow stimulation on the absorbed radiation dose to the salivary glands during radioiodine therapy of thyroid cancer using 124I PET(/CT) imaging.

European Journal of Nuclear Medicine and Molecular Imaging
Walter JentzenAlexander Stahl

Abstract

A serious side effect of high-activity radioiodine therapy in the treatment of differentiated thyroid cancer is radiogenic salivary gland damage. This damage may be diminished by lemon-juice-induced saliva flow immediately after 131I administration. The aim of this study was to assess the effect of chewing lemon slices on the absorbed (radiation) doses to the salivary glands. Ten patients received (pretherapy) 124I PET(/CT) dosimetry before their first radioiodine therapy. The patients underwent a series of six PET scans at 0.5, 1, 2, 4, 48 and ≥96 h and one PET/CT scan at 24 h after administration of 27 MBq 124I. Blood samples were also collected at about 2, 4, 24, 48, and 96 h. Contrary to the standard radioiodine therapy protocol, the patients were not stimulated with lemon juice. Specifically, the patients chewed no lemon slices during the pretherapy procedure and neither ate food nor drank fluids until after completion of the last PET scan on the first day. Organ absorbed doses per administered 131I activity (ODpAs) as well as gland and blood uptake curves were determined and compared with published data from a control patient group, i.e. stimulated per the standard radioiodine therapy protocol. The calculations for both g...Continue Reading

References

May 6, 2003·Thyroid : Official Journal of the American Thyroid Association·Susan J Mandel, Louis Mandel
Jul 3, 2004·European Radiology·L S FreudenbergW Brandau
Feb 20, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·S HyerC Harmer
Oct 12, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Walter JentzenAndreas Bockisch
Aug 2, 2008·European Journal of Nuclear Medicine and Molecular Imaging·M LusterUNKNOWN European Association of Nuclear Medicine (EANM)
Jun 9, 2009·Thyroid : Official Journal of the American Thyroid Association·Douglas Van NostrandLeonard Wartofsky
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle

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Citations

Apr 13, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Lutz S FreudenbergSandra J Rosenbaum-Krumme
Aug 2, 2013·Future Oncology·Zohreh Noaparast, Seyed Jalal Hosseinimehr
Jul 2, 2014·Nature Reviews. Endocrinology·Markus LusterFrederik A Verburg
Jul 26, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Andri ChristouAndreas Charalambous
Nov 11, 2016·Cancer Biotherapy & Radiopharmaceuticals·Demetrios Okkalides
Apr 25, 2017·Pediatric Blood & Cancer·Domenico AlbanoRaffaele Giubbini
Mar 9, 2018·Nuclear Medicine Communications·Mahdi HaghighatafsharTahereh Ghaedian
Apr 3, 2020·European Journal of Oral Sciences·Eva KrčálováJiří Doležal
Feb 27, 2018·Oral Diseases·G Sunavala-Dossabhoy
Apr 27, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Mahdi HaghighatafsharTahereh Ghaedian
Jun 26, 2020·Nuclear Medicine and Molecular Imaging·Byeong-Cheol Ahn
Sep 9, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Xiaofeng WangYong Cheng
Mar 10, 2021·European Journal of Nuclear Medicine and Molecular Imaging·V MohanWouter V Vogel
Jun 19, 2021·Hormones : International Journal of Endocrinology and Metabolism·Marios AdramerinasKalliopi Pazaitou-Panayiotou
Oct 9, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Steffie M B PetersWalter Jentzen

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